Increased Glutamine Synthetase immunoreactivity in experimental pneumococcal meningitis

AK Stringaris; W Bruck; Hayrettin  Tumani; Holger  Schmidt; R Nau

doi:10.1007/s004010050606

Increased Glutamine Synthetase immunoreactivity in experimental pneumococcal meningitis

AK Stringaris, W Bruck, Hayrettin Tumani, Holger Schmidt, R Nau

Child & Adolescent Psychiatry

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Abstract

Glutamine synthetase (GS), glial fibrillary acidic protein (GFAP) immunohistochemistry and neuronal apoptotic cell death were evaluated in a rabbit model of pneumococcal meningitis. Meningitis caused an increase of GS immunoreactivity in the cerebral cortex, but not in the hippocampal formation. GFAP immunoreactivity remained unchanged. This may represent a protective mechanism for cortical neurons. The inability of hippocampal GS to counteract the detrimental effects of glutamate may be the cause of neuronal apoptosis observed in the dentate gyrus during meningitis.

Original language	English
Pages (from-to)	215 - 218
Number of pages	4
Journal	Acta Neuropathologica
Volume	93
Issue number	3
DOIs	https://doi.org/10.1007/s004010050606
Publication status	Published - Mar 1997

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title = "Increased Glutamine Synthetase immunoreactivity in experimental pneumococcal meningitis",

abstract = "Glutamine synthetase (GS), glial fibrillary acidic protein (GFAP) immunohistochemistry and neuronal apoptotic cell death were evaluated in a rabbit model of pneumococcal meningitis. Meningitis caused an increase of GS immunoreactivity in the cerebral cortex, but not in the hippocampal formation. GFAP immunoreactivity remained unchanged. This may represent a protective mechanism for cortical neurons. The inability of hippocampal GS to counteract the detrimental effects of glutamate may be the cause of neuronal apoptosis observed in the dentate gyrus during meningitis.",

author = "AK Stringaris and W Bruck and Hayrettin Tumani and Holger Schmidt and R Nau",

year = "1997",

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T1 - Increased Glutamine Synthetase immunoreactivity in experimental pneumococcal meningitis

AU - Stringaris, AK

AU - Bruck, W

AU - Tumani, Hayrettin

AU - Schmidt, Holger

AU - Nau, R

PY - 1997/3

Y1 - 1997/3

N2 - Glutamine synthetase (GS), glial fibrillary acidic protein (GFAP) immunohistochemistry and neuronal apoptotic cell death were evaluated in a rabbit model of pneumococcal meningitis. Meningitis caused an increase of GS immunoreactivity in the cerebral cortex, but not in the hippocampal formation. GFAP immunoreactivity remained unchanged. This may represent a protective mechanism for cortical neurons. The inability of hippocampal GS to counteract the detrimental effects of glutamate may be the cause of neuronal apoptosis observed in the dentate gyrus during meningitis.

AB - Glutamine synthetase (GS), glial fibrillary acidic protein (GFAP) immunohistochemistry and neuronal apoptotic cell death were evaluated in a rabbit model of pneumococcal meningitis. Meningitis caused an increase of GS immunoreactivity in the cerebral cortex, but not in the hippocampal formation. GFAP immunoreactivity remained unchanged. This may represent a protective mechanism for cortical neurons. The inability of hippocampal GS to counteract the detrimental effects of glutamate may be the cause of neuronal apoptosis observed in the dentate gyrus during meningitis.

U2 - 10.1007/s004010050606

DO - 10.1007/s004010050606

M3 - Article

SN - 0001-6322

VL - 93

SP - 215

EP - 218

JO - Acta Neuropathologica

JF - Acta Neuropathologica

IS - 3

ER -

Increased Glutamine Synthetase immunoreactivity in experimental pneumococcal meningitis

Abstract

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