Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use

TY - JOUR

T1 - Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use

AU - Ryu, Yeonsuk

AU - Gracia-Lor, Emma

AU - Bade, Richard

AU - Baz-Lomba, J. A.

AU - Bramness, Jørgen G.

AU - Castiglioni, Sara

AU - Castrignanò, Erika

AU - Causanilles, Ana

AU - Covaci, Adrian

AU - De Voogt, Pim

AU - Hernandez, Felix

AU - Kasprzyk-Hordern, Barbara

AU - Kinyua, Juliet

AU - McCall, Ann Kathrin

AU - Ort, Christoph

AU - Plósz, Benedek G.

AU - Ramin, Pedram

AU - Rousis, Nikolaos I.

AU - Reid, Malcolm J.

AU - Thomas, Kevin V.

N1 - Publisher Copyright: © 2016 The Author(s).

PY - 2016/12/15

Y1 - 2016/12/15

N2 - Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F2-isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F2α (8-iso-PGF 2α) was analysed in raw 24 h-composite wastewater samples collected from 4 Norwegian and 7 other European cities in 2014 and 2015. Using the same samples, biomarkers of alcohol (ethyl sulfate) and tobacco (trans-3′-hydroxycotinine) use were also analysed to investigate any possible correlation between 8-iso-PGF2α and the consumption of the two drugs. The estimated per capita daily loads of 8-iso-PGF2α in the 11 cities ranged between 2.5 and 9.9 mg/day/1000 inhabitants with a population-weighted mean of 4.8 mg/day/1000 inhabitants. There were no temporal trends observed in the levels of 8-iso-PGF 2α, however, spatial differences were found at the inter-city level correlating to the degree of urbanisation. The 8-iso-PGF2α mass load was found to be strongly associated with that of trans-3′-hydroxycotinine while it showed no correlation with ethyl sulfate. The present study shows the potential for 8-iso-PGF2α as a wastewater biomarker for the assessment of community public health.

AB - Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F2-isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F2α (8-iso-PGF 2α) was analysed in raw 24 h-composite wastewater samples collected from 4 Norwegian and 7 other European cities in 2014 and 2015. Using the same samples, biomarkers of alcohol (ethyl sulfate) and tobacco (trans-3′-hydroxycotinine) use were also analysed to investigate any possible correlation between 8-iso-PGF2α and the consumption of the two drugs. The estimated per capita daily loads of 8-iso-PGF2α in the 11 cities ranged between 2.5 and 9.9 mg/day/1000 inhabitants with a population-weighted mean of 4.8 mg/day/1000 inhabitants. There were no temporal trends observed in the levels of 8-iso-PGF 2α, however, spatial differences were found at the inter-city level correlating to the degree of urbanisation. The 8-iso-PGF2α mass load was found to be strongly associated with that of trans-3′-hydroxycotinine while it showed no correlation with ethyl sulfate. The present study shows the potential for 8-iso-PGF2α as a wastewater biomarker for the assessment of community public health.

UR - http://www.scopus.com/inward/record.url?scp=85006325337&partnerID=8YFLogxK

U2 - 10.1038/srep39055

DO - 10.1038/srep39055

M3 - Article

C2 - 27976726

AN - SCOPUS:85006325337

SN - 2045-2322

VL - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 39055

ER -