Increased metabolism in the R6/2 mouse model of Huntington's disease

J M M van der Burg; K Bacos; N I Wood; A Lindqvist; N Wierup; B Woodman; J I Wamsteeker; R Smith; T Deierborg; M J Kuhar; G P Bates; H Mulder; C Erlanson-Albertsson; A J Morton; P Brundin; A Petersen; M Bjorkqvist

doi:10.1016/j.nbd.2007.07.029

Increased metabolism in the R6/2 mouse model of Huntington's disease

J M M van der Burg, K Bacos, N I Wood, A Lindqvist, N Wierup, B Woodman, J I Wamsteeker, R Smith, T Deierborg, M J Kuhar, G P Bates, H Mulder, C Erlanson-Albertsson, A J Morton, P Brundin, A Petersen, M Bjorkqvist

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Abstract

Huntington's disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is unknown. The aim of this study was to examine body weight changes and weight-regulating factors in HD using the R6/2 mouse model as a tool. We found that R6/2 mice started losing weight at 9 weeks of age. Total locomotor activity was unaltered and caloric intake was not decreased until 11 weeks of age, which led us to hypothesize that increased metabolism might underlie the weight loss. Indeed, oxygen consumption in R6/2 mice was elevated from 6 weeks of age, indicative of an increased metabolism. Several organ systems that regulate weight and metabolism, including the hypothalamus, the stomach and adipose tissue displayed abnormalities in R6/2 mice. Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors. (c) 2007 Elsevier Inc. All rights reserved

Original language	English
Pages (from-to)	41 - 51
Number of pages	11
Journal	Neurobiology of Disease
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.nbd.2007.07.029
Publication status	Published - Jan 2008

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van der Burg, J. M. M., Bacos, K., Wood, N. I., Lindqvist, A., Wierup, N., Woodman, B., Wamsteeker, J. I., Smith, R., Deierborg, T., Kuhar, M. J., Bates, G. P., Mulder, H., Erlanson-Albertsson, C., Morton, A. J., Brundin, P., Petersen, A., & Bjorkqvist, M. (2008). Increased metabolism in the R6/2 mouse model of Huntington's disease. Neurobiology of Disease, 29(1), 41 - 51. https://doi.org/10.1016/j.nbd.2007.07.029

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title = "Increased metabolism in the R6/2 mouse model of Huntington's disease",

abstract = "Huntington's disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is unknown. The aim of this study was to examine body weight changes and weight-regulating factors in HD using the R6/2 mouse model as a tool. We found that R6/2 mice started losing weight at 9 weeks of age. Total locomotor activity was unaltered and caloric intake was not decreased until 11 weeks of age, which led us to hypothesize that increased metabolism might underlie the weight loss. Indeed, oxygen consumption in R6/2 mice was elevated from 6 weeks of age, indicative of an increased metabolism. Several organ systems that regulate weight and metabolism, including the hypothalamus, the stomach and adipose tissue displayed abnormalities in R6/2 mice. Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors. (c) 2007 Elsevier Inc. All rights reserved",

author = "{van der Burg}, {J M M} and K Bacos and Wood, {N I} and A Lindqvist and N Wierup and B Woodman and Wamsteeker, {J I} and R Smith and T Deierborg and Kuhar, {M J} and Bates, {G P} and H Mulder and C Erlanson-Albertsson and Morton, {A J} and P Brundin and A Petersen and M Bjorkqvist",

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doi = "10.1016/j.nbd.2007.07.029",

language = "English",

volume = "29",

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van der Burg, JMM, Bacos, K, Wood, NI, Lindqvist, A, Wierup, N, Woodman, B, Wamsteeker, JI, Smith, R, Deierborg, T, Kuhar, MJ, Bates, GP, Mulder, H, Erlanson-Albertsson, C, Morton, AJ, Brundin, P, Petersen, A & Bjorkqvist, M 2008, 'Increased metabolism in the R6/2 mouse model of Huntington's disease', Neurobiology of Disease, vol. 29, no. 1, pp. 41 - 51. https://doi.org/10.1016/j.nbd.2007.07.029

TY - JOUR

T1 - Increased metabolism in the R6/2 mouse model of Huntington's disease

AU - van der Burg, J M M

AU - Bacos, K

AU - Wood, N I

AU - Lindqvist, A

AU - Wierup, N

AU - Woodman, B

AU - Wamsteeker, J I

AU - Smith, R

AU - Deierborg, T

AU - Kuhar, M J

AU - Bates, G P

AU - Mulder, H

AU - Erlanson-Albertsson, C

AU - Morton, A J

AU - Brundin, P

AU - Petersen, A

AU - Bjorkqvist, M

PY - 2008/1

Y1 - 2008/1

N2 - Huntington's disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is unknown. The aim of this study was to examine body weight changes and weight-regulating factors in HD using the R6/2 mouse model as a tool. We found that R6/2 mice started losing weight at 9 weeks of age. Total locomotor activity was unaltered and caloric intake was not decreased until 11 weeks of age, which led us to hypothesize that increased metabolism might underlie the weight loss. Indeed, oxygen consumption in R6/2 mice was elevated from 6 weeks of age, indicative of an increased metabolism. Several organ systems that regulate weight and metabolism, including the hypothalamus, the stomach and adipose tissue displayed abnormalities in R6/2 mice. Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors. (c) 2007 Elsevier Inc. All rights reserved

AB - Huntington's disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is unknown. The aim of this study was to examine body weight changes and weight-regulating factors in HD using the R6/2 mouse model as a tool. We found that R6/2 mice started losing weight at 9 weeks of age. Total locomotor activity was unaltered and caloric intake was not decreased until 11 weeks of age, which led us to hypothesize that increased metabolism might underlie the weight loss. Indeed, oxygen consumption in R6/2 mice was elevated from 6 weeks of age, indicative of an increased metabolism. Several organ systems that regulate weight and metabolism, including the hypothalamus, the stomach and adipose tissue displayed abnormalities in R6/2 mice. Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors. (c) 2007 Elsevier Inc. All rights reserved

U2 - 10.1016/j.nbd.2007.07.029

DO - 10.1016/j.nbd.2007.07.029

M3 - Article

VL - 29

SP - 41

EP - 51

JO - Neurobiology of Disease

JF - Neurobiology of Disease

IS - 1

ER -

Increased metabolism in the R6/2 mouse model of Huntington's disease

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