Increased myogenic tone precedes structural changes in mild experimental uraemia in the absence of hypertension in rats

TY - JOUR

T1 - Increased myogenic tone precedes structural changes in mild experimental uraemia in the absence of hypertension in rats

AU - Savage, T

AU - McMahon, A C

AU - Mullen, A M

AU - Nott, C A

AU - Dodd, S M

AU - Tribe, R M

AU - Yaqoob, M M

PY - 1998/12

Y1 - 1998/12

N2 - 1. Mechanical forces associated with blood flow play important roles in the acute control of vascular tone, the regulation of arterial structure and remodelling and the localization of atherosclerotic plaque. Uraemia is a proatherogenic process and is expected to be associated with impaired vascular reactivity.2. To study this, 12 male Wistar rats were rendered uraemic by five-sixths nephrectomy and 12 control rats were sham operated simultaneously. After 8 weeks a tail-cuff systolic blood pressure was recorded, blood samples were taken and the animals killed. Isolated femoral arteries were dissected and mounted on a pressure myograph and myogenic tone was assessed over a range of intravascular pressures from 40 to 160 mmHg. Histologically the arteries were comparatively examined for gross morphology, calcification and deposition of collagen.3.Biochemically the serum urea and creatinine were greater in the uraemic compared with the control rats (urea: 23.5+/-6 mmol/l and 6.8+/-01 mmol/l respectively, P not significant; creatinine: 130.7+/-13 mmol/l and 70.3+/-5 mmol/l respectively, P

AB - 1. Mechanical forces associated with blood flow play important roles in the acute control of vascular tone, the regulation of arterial structure and remodelling and the localization of atherosclerotic plaque. Uraemia is a proatherogenic process and is expected to be associated with impaired vascular reactivity.2. To study this, 12 male Wistar rats were rendered uraemic by five-sixths nephrectomy and 12 control rats were sham operated simultaneously. After 8 weeks a tail-cuff systolic blood pressure was recorded, blood samples were taken and the animals killed. Isolated femoral arteries were dissected and mounted on a pressure myograph and myogenic tone was assessed over a range of intravascular pressures from 40 to 160 mmHg. Histologically the arteries were comparatively examined for gross morphology, calcification and deposition of collagen.3.Biochemically the serum urea and creatinine were greater in the uraemic compared with the control rats (urea: 23.5+/-6 mmol/l and 6.8+/-01 mmol/l respectively, P not significant; creatinine: 130.7+/-13 mmol/l and 70.3+/-5 mmol/l respectively, P

KW - Animals

KW - Femoral Artery

KW - Male

KW - Muscle, Smooth, Vascular

KW - Myography

KW - Nephrectomy

KW - Rats

KW - Rats, Wistar

KW - Time Factors

KW - Uremia

M3 - Article

C2 - 9831692

SN - 0143-5221

VL - 95

SP - 681

EP - 686

JO - Clinical Science

JF - Clinical Science

IS - 6

ER -