Increased serum soluble Fas in patients with acute liver failure due to paracetamol overdose

A Tagami, H Ohnishi, R D Hughes

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    24 Citations (Scopus)

    Abstract

    Background/Aims: Experimental studies have suggested that apoptosis via the Fas/Fas Ligand signaling system may play an important role in the development of acute liver failure. The aim of the study was to investigate the soluble form of Fas in patients with acute liver failure. Methodology: Serum levels of sFas (soluble Fas) were measured by ELISA in 24 patients with acute liver failure and 10 normal control subjects. Serum levels of tumor necrosis factor-alpha and interferon-y were also determined by ELISA. Results: Serum sFas was significantly increased in patients with acute liver failure (median, 26.8 U/mL; range, 6.9-52.7 U/mL) compared to the normal controls (median, 8.6 U/mL; range, 6.5-12.0 U/mL, P
    Original languageEnglish
    Pages (from-to)742 - 745
    Number of pages4
    JournalHepato-Gastroenterology
    Volume50
    Issue number51
    Publication statusPublished - May 2003

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