Independent Vesicle Pools Underlie Different Modes of Release during Neuronal Development

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47 Citations (Scopus)

Abstract

Mature presynaptic terminals release neurotransmitter both in response to activity and spontaneously. We found that axons of rat hippocampal neurons initially show very high levels of exclusively spontaneous release, which progressively switches over to the mature phenotype during synapse formation. These two modes of vesicle cycling derive from distinct pools throughout development and the initiation of activity-dependent release was independent of postsynaptic contacts, suggesting it is an autonomous presynaptic event.
Original languageEnglish
Pages (from-to)1867 - 1874
Number of pages8
JournalJournal of Neuroscience
Volume32
Issue number5
DOIs
Publication statusPublished - 1 Feb 2012

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