@article{a308fefd681e4e109e8644044080812d,
title = "Individual behavioral trajectories shape whole-brain connectivity in mice.",
abstract = "It is widely assumed that our actions shape our brains and that the resulting connections determine who we are. To test this idea in a reductionist setting, in which genes and environment are controlled, we investigated differences in neuroanatomy and structural covariance by ex vivo structural magnetic resonance imaging (MRI) in mice whose behavioral activity was continuously tracked for 3 months in a large, enriched environment. We confirmed that environmental enrichment increases mouse hippocampal volumes. Stratifying the enriched group according to individual longitudinal behavioral trajectories, however, revealed striking differences in mouse brain structural covariance in continuously highly active mice compared to those whose trajectories showed signs of habituating activity. Network-based statistics identified distinct sub-networks of murine structural covariance underlying these differences in behavioral activity. Together, these results reveal that differentiated behavioral trajectories of mice in an enriched environment are associated with differences in brain connectivity. ",
author = "{Bogado Lopes}, Jadna and Anna Senko and Klaas Bahnsen and Daniel Geisler and Eugene Kim and {Soares Mesquita}, {Michel Bernanos} and Diana Cash and Stefan Ehrlich and Anthony Vernon and Gerd Kempermann",
note = "Funding Information: F unding: Helmholtz Association (GK, ANS); Technische Universit{\"a}t Dresden (GK, ANS); C oordination for the Improvement of Higher Education Personnel (CAPES), Brazil (DOC P leno / Processo nr.(츀 88881.129646/2016-01) (JBL); The JoachimH erz Foundation ( JBL); Medical Research Council (New Investigator Research Grant MR/N025377/1 ( AV); Centre Grant MR/N026063/1) (AV); TransCampus (TU Dresden and King{\textquoteright}s Col- l ege London) research award (AV, GK); DFG research grant: EH 367/7-1 {"}Dynamische V er{\"a}nderungen des strukturellen und funktionellen Hirn-Konnektoms bei Patientinnen m it Anorexia Nervosa{"} (SE). S upplementary Material Legends Funding Information: Helmholtz Association (GK, ANS); Technische Universit{\"a}t Dresden (GK, ANS); Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil (DOC Pleno / Processo nr. 88881.129646/2016-01) (JBL); The Joachim Herz Foundation (JBL); Medical Research Council (New Investigator Research Grant MR/N025377/1 (AV); Centre Grant MR/N026063/1) (AV); TransCampus (TU Dresden and King{\textquoteright}s College London) research award (AV, GK); DFG research grant: EH 367/7-1 {"}Dynamische Ver{\"a}nderungen des strukturellen und funktionellen Hirn-Konnektoms bei Patientinnen mit Anorexia Nervosa{"} (SE). Publisher Copyright: {\textcopyright} 2023, eLife Sciences Publications Ltd. All rights reserved.",
year = "2023",
month = jan,
day = "16",
doi = "10.7554/eLife.80379",
language = "English",
volume = "12",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications, Ltd",
}