Individual focused studies of functional brain development in early human infancy

Tanya Poppe; Jucha Willers Moore; Tomoki Arichi

doi:https://doi.org/10.1016/j.cobeha.2021.04.017

Individual focused studies of functional brain development in early human infancy

Tanya Poppe, Jucha Willers Moore, Tomoki Arichi^*

^*Corresponding author for this work

MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom.

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Across the perinatal period, the human brain undergoes a rapid yet highly programmed sequence of maturation. In this time, neural activity has a key role in establishing the brain's early circuits and guiding essential processes including cell differentiation, neuronal and axonal growth, arborization and synaptogenesis. fMRI studies of young infants hold great potential to understand developmental changes in systems-wide activity and their relationship to regional growth and development. These studies have shown that the brain's activity rapidly evolves across the perinatal period, as neurovascular coupling matures and resting state networks are established. The high variability of spatial and temporal properties in functional activity may be attributed to the sensitivity of neurovascular coupling to developing cellular structure and connectivity as well as fluctuations in cerebral physiology, behavioral state, and pathology. Longitudinal studies may precisely explore these relationships and provide mechanistic understanding of the relationship between physiology, behavior, injury, and functional activity.

Original language	English
Pages (from-to)	137-143
Number of pages	7
Journal	Current Opinion in Behavioral Sciences
Volume	40
Early online date	2021
DOIs	https://doi.org/10.1016/j.cobeha.2021.04.017
Publication status	Published - Aug 2021

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@article{ba424957cfe142ef959132b61d5d8a9f,

title = "Individual focused studies of functional brain development in early human infancy",

abstract = "Across the perinatal period, the human brain undergoes a rapid yet highly programmed sequence of maturation. In this time, neural activity has a key role in establishing the brain's early circuits and guiding essential processes including cell differentiation, neuronal and axonal growth, arborization and synaptogenesis. fMRI studies of young infants hold great potential to understand developmental changes in systems-wide activity and their relationship to regional growth and development. These studies have shown that the brain's activity rapidly evolves across the perinatal period, as neurovascular coupling matures and resting state networks are established. The high variability of spatial and temporal properties in functional activity may be attributed to the sensitivity of neurovascular coupling to developing cellular structure and connectivity as well as fluctuations in cerebral physiology, behavioral state, and pathology. Longitudinal studies may precisely explore these relationships and provide mechanistic understanding of the relationship between physiology, behavior, injury, and functional activity.",

author = "Tanya Poppe and {Willers Moore}, Jucha and Tomoki Arichi",

note = "Funding Information: TP and TA are supported by funding from a Medical Research Council (MRC) UK Clinician Scientist Fellowship [MR/P008712/1, MR/V036874/1]. JWM is in receipt of PhD funding support from the Medical Research Council Centre for Neurodevelopmental Disorders, King's College London [MR/N026063/1]. The authors additionally acknowledge support from the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas? NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust, and the Wellcome Engineering and Physical Sciences Research Council (EPSRC) Centre for Medical Engineering at Kings College London [WT 203148/Z/16/Z]. Funding Information: TP and TA are supported by funding from a Medical Research Council (MRC) UK Clinician Scientist Fellowship [ MR/P008712/1 , MR/V036874/1 ]. JWM is in receipt of PhD funding support from the M edical Research Council Centre for Neurodevelopmental Disorders, King{\textquoteright}s College London [ MR/N026063/1 ]. The authors additionally acknowledge support from the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy{\textquoteright}s & St Thomas{\textquoteright} NHS Foundation Trust in partnership with King{\textquoteright}s College London and King{\textquoteright}s College Hospital NHS Foundation Trust , and the Wellcome Engineering and Physical Sciences Research Council ( EPSRC ) Centre for Medical Engineering at Kings College London [ WT 203148/Z/16/Z ]. Publisher Copyright: {\textcopyright} 2021 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = aug,

doi = "https://doi.org/10.1016/j.cobeha.2021.04.017",

language = "English",

volume = "40",

pages = "137--143",

journal = "Current Opinion in Behavioral Sciences",

issn = "2352-1546",

publisher = "Elsevier Limited",

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T1 - Individual focused studies of functional brain development in early human infancy

AU - Poppe, Tanya

AU - Willers Moore, Jucha

AU - Arichi, Tomoki

N1 - Funding Information: TP and TA are supported by funding from a Medical Research Council (MRC) UK Clinician Scientist Fellowship [MR/P008712/1, MR/V036874/1]. JWM is in receipt of PhD funding support from the Medical Research Council Centre for Neurodevelopmental Disorders, King's College London [MR/N026063/1]. The authors additionally acknowledge support from the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas? NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust, and the Wellcome Engineering and Physical Sciences Research Council (EPSRC) Centre for Medical Engineering at Kings College London [WT 203148/Z/16/Z]. Funding Information: TP and TA are supported by funding from a Medical Research Council (MRC) UK Clinician Scientist Fellowship [ MR/P008712/1 , MR/V036874/1 ]. JWM is in receipt of PhD funding support from the M edical Research Council Centre for Neurodevelopmental Disorders, King’s College London [ MR/N026063/1 ]. The authors additionally acknowledge support from the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy’s & St Thomas’ NHS Foundation Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust , and the Wellcome Engineering and Physical Sciences Research Council ( EPSRC ) Centre for Medical Engineering at Kings College London [ WT 203148/Z/16/Z ]. Publisher Copyright: © 2021 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/8

Y1 - 2021/8

N2 - Across the perinatal period, the human brain undergoes a rapid yet highly programmed sequence of maturation. In this time, neural activity has a key role in establishing the brain's early circuits and guiding essential processes including cell differentiation, neuronal and axonal growth, arborization and synaptogenesis. fMRI studies of young infants hold great potential to understand developmental changes in systems-wide activity and their relationship to regional growth and development. These studies have shown that the brain's activity rapidly evolves across the perinatal period, as neurovascular coupling matures and resting state networks are established. The high variability of spatial and temporal properties in functional activity may be attributed to the sensitivity of neurovascular coupling to developing cellular structure and connectivity as well as fluctuations in cerebral physiology, behavioral state, and pathology. Longitudinal studies may precisely explore these relationships and provide mechanistic understanding of the relationship between physiology, behavior, injury, and functional activity.

AB - Across the perinatal period, the human brain undergoes a rapid yet highly programmed sequence of maturation. In this time, neural activity has a key role in establishing the brain's early circuits and guiding essential processes including cell differentiation, neuronal and axonal growth, arborization and synaptogenesis. fMRI studies of young infants hold great potential to understand developmental changes in systems-wide activity and their relationship to regional growth and development. These studies have shown that the brain's activity rapidly evolves across the perinatal period, as neurovascular coupling matures and resting state networks are established. The high variability of spatial and temporal properties in functional activity may be attributed to the sensitivity of neurovascular coupling to developing cellular structure and connectivity as well as fluctuations in cerebral physiology, behavioral state, and pathology. Longitudinal studies may precisely explore these relationships and provide mechanistic understanding of the relationship between physiology, behavior, injury, and functional activity.

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U2 - https://doi.org/10.1016/j.cobeha.2021.04.017

DO - https://doi.org/10.1016/j.cobeha.2021.04.017

M3 - Review article

SN - 2352-1546

VL - 40

SP - 137

EP - 143

JO - Current Opinion in Behavioral Sciences

JF - Current Opinion in Behavioral Sciences

ER -

Individual focused studies of functional brain development in early human infancy

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