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Individual limb muscle bundles are formed through progressive steps orchestrated by adjacent irregular connective tissue fibroblasts during primary myogenesis

Research output: Contribution to journalArticle

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Individual limb muscle bundles are formed through progressive steps orchestrated by adjacent irregular connective tissue fibroblasts during primary myogenesis. / Logan, Malcolm P O; Besse, Laurianne Marie; Daniel Sunder Singh, Caroline Jeya Sheeba; Holt, Mark Robert; Miller, Susan Mary; Feneck, Eleanor Mai; Bell, Donald; Kucharska, Ania.

In: Cell Reports, 2020.

Research output: Contribution to journalArticle

Harvard

Logan, MPO, Besse, LM, Daniel Sunder Singh, CJS, Holt, MR, Miller, SM, Feneck, EM, Bell, D & Kucharska, A 2020, 'Individual limb muscle bundles are formed through progressive steps orchestrated by adjacent irregular connective tissue fibroblasts during primary myogenesis', Cell Reports.

APA

Logan, M. P. O., Besse, L. M., Daniel Sunder Singh, C. J. S., Holt, M. R., Miller, S. M., Feneck, E. M., ... Kucharska, A. (2020). Individual limb muscle bundles are formed through progressive steps orchestrated by adjacent irregular connective tissue fibroblasts during primary myogenesis. Cell Reports.

Vancouver

Logan MPO, Besse LM, Daniel Sunder Singh CJS, Holt MR, Miller SM, Feneck EM et al. Individual limb muscle bundles are formed through progressive steps orchestrated by adjacent irregular connective tissue fibroblasts during primary myogenesis. Cell Reports. 2020.

Author

Logan, Malcolm P O ; Besse, Laurianne Marie ; Daniel Sunder Singh, Caroline Jeya Sheeba ; Holt, Mark Robert ; Miller, Susan Mary ; Feneck, Eleanor Mai ; Bell, Donald ; Kucharska, Ania. / Individual limb muscle bundles are formed through progressive steps orchestrated by adjacent irregular connective tissue fibroblasts during primary myogenesis. In: Cell Reports. 2020.

Bibtex Download

@article{e4dc076045864e4dae78c6379c0d65dc,
title = "Individual limb muscle bundles are formed through progressive steps orchestrated by adjacent irregular connective tissue fibroblasts during primary myogenesis",
abstract = "Although the factors regulating muscle cell differentiation are well described, we know very little about how differentiating muscle fibres are organised into individual muscle tissue bundles. Disruption of these processes leads to muscle hypoplasia or dysplasia and replicating these events is vital in tissue engineering approaches. We describe the progressive cellular events that orchestrate the formation of individual limb muscle bundles and directly demonstrate the role of the connective tissue cells that surround muscle precursors in controlling these events. We show how disruption of gene activity within or genetic ablation of connective tissue cells impacts on muscle precursors causing disruption of muscle bundle formation and subsequent muscle dysplasia and hypoplasia. We identify several novel markers of the populations of connective tissue cells that surround muscle precursors and provide a model for how matrix-modifying proteoglycans secreted by these cells may influence muscle bundle formation via effects on the local ECM environment.",
author = "Logan, {Malcolm P O} and Besse, {Laurianne Marie} and {Daniel Sunder Singh}, {Caroline Jeya Sheeba} and Holt, {Mark Robert} and Miller, {Susan Mary} and Feneck, {Eleanor Mai} and Donald Bell and Ania Kucharska",
year = "2020",
language = "English",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Elsevier BV",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Individual limb muscle bundles are formed through progressive steps orchestrated by adjacent irregular connective tissue fibroblasts during primary myogenesis

AU - Logan, Malcolm P O

AU - Besse, Laurianne Marie

AU - Daniel Sunder Singh, Caroline Jeya Sheeba

AU - Holt, Mark Robert

AU - Miller, Susan Mary

AU - Feneck, Eleanor Mai

AU - Bell, Donald

AU - Kucharska, Ania

PY - 2020

Y1 - 2020

N2 - Although the factors regulating muscle cell differentiation are well described, we know very little about how differentiating muscle fibres are organised into individual muscle tissue bundles. Disruption of these processes leads to muscle hypoplasia or dysplasia and replicating these events is vital in tissue engineering approaches. We describe the progressive cellular events that orchestrate the formation of individual limb muscle bundles and directly demonstrate the role of the connective tissue cells that surround muscle precursors in controlling these events. We show how disruption of gene activity within or genetic ablation of connective tissue cells impacts on muscle precursors causing disruption of muscle bundle formation and subsequent muscle dysplasia and hypoplasia. We identify several novel markers of the populations of connective tissue cells that surround muscle precursors and provide a model for how matrix-modifying proteoglycans secreted by these cells may influence muscle bundle formation via effects on the local ECM environment.

AB - Although the factors regulating muscle cell differentiation are well described, we know very little about how differentiating muscle fibres are organised into individual muscle tissue bundles. Disruption of these processes leads to muscle hypoplasia or dysplasia and replicating these events is vital in tissue engineering approaches. We describe the progressive cellular events that orchestrate the formation of individual limb muscle bundles and directly demonstrate the role of the connective tissue cells that surround muscle precursors in controlling these events. We show how disruption of gene activity within or genetic ablation of connective tissue cells impacts on muscle precursors causing disruption of muscle bundle formation and subsequent muscle dysplasia and hypoplasia. We identify several novel markers of the populations of connective tissue cells that surround muscle precursors and provide a model for how matrix-modifying proteoglycans secreted by these cells may influence muscle bundle formation via effects on the local ECM environment.

M3 - Article

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

ER -

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