Induced pluripotent stem cell therapies for degenerative disease of the outer retina: Disease modeling and cell replacement

Valentina Di Foggia, Priyanka Makwana, Robin R. Ali, Jane C. Sowden*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Stem cell therapies are being explored as potential treatments for retinal disease. How to replace neurons in a degenerated retina presents a continued challenge for the regenerative medicine field that, if achieved, could restore sight. The major issues are: (i) the source and availability of donor cells for transplantation; (ii) the differentiation of stem cells into the required retinal cells; and (iii) the delivery, integration, functionality, and survival of new cells in the host neural network. This review considers the use of induced pluripotent stem cells (iPSC), currently under intense investigation, as a platform for cell transplantation therapy. Moreover, patient-specific iPSC are being developed for autologous cell transplantation and as a tool for modeling specific retinal diseases, testing gene therapies, and drug screening.

Original languageEnglish
Pages (from-to)240-252
Number of pages13
JournalJournal of Ocular Pharmacology and Therapeutics
Volume32
Issue number5
DOIs
Publication statusPublished - 1 Jun 2016

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