Induced pluripotent stem cells- alchemist's tale or clinical reality?

Tamir Rashid, Ludovic Vallier

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Following Shinya Yamanaka's first report describing the reprogramming of fibroblasts into stem cells over three years ago, some sceptics initially drew analogies between this new field of research and the quasi-mystical practice of 'alchemy'. Unlike the alchemist, however, stem cell researchers have rigorously tested and repeated experiments, proving their very own brand of cellular 'alchemy' to be a reality, with potentially massive implications for the study of human biology and clinical medicine. These investigations have resulted in an explosion of related publications and initiated the field of stem cell research known as 'induced pluripotency'. In this review, we give an account of the historical development, current technologies and potential clinical applications of induced pluripotency and conclude with a perspective on the possible future directions for this dynamic field.
Original languageEnglish
Pages (from-to)e25
Number of pages1
JournalEXPERT REVIEWS IN MOLECULAR MEDICINE
Volume12
DOIs
Publication statusPublished - 2010

Keywords

  • Clinical Trials as Topic
  • Embryonic Stem Cells
  • Humans
  • Induced Pluripotent Stem Cells
  • Models, Biological
  • Nuclear Reprogramming
  • Regenerative Medicine

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