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Inflammation and metabolic changes in First Episode Psychosis: Preliminary results from a longitudinal study

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Inflammation and metabolic changes in First Episode Psychosis : Preliminary results from a longitudinal study. / Russell, Alice; Ciufolini, Simone; Gardner-Sood, Poonam; Bonaccorso, Stefania; Gaughran, Fiona; Dazzan, Paola; Pariante, Carmine M; Mondelli, Valeria.

In: Brain Behavior and Immunity, Vol. 49, 10.2015, p. 25–29.

Research output: Contribution to journalArticle

Harvard

Russell, A, Ciufolini, S, Gardner-Sood, P, Bonaccorso, S, Gaughran, F, Dazzan, P, Pariante, CM & Mondelli, V 2015, 'Inflammation and metabolic changes in First Episode Psychosis: Preliminary results from a longitudinal study' Brain Behavior and Immunity, vol 49, pp. 25–29. DOI: 10.1016/j.bbi.2015.06.004

APA

Russell, A., Ciufolini, S., Gardner-Sood, P., Bonaccorso, S., Gaughran, F., Dazzan, P., ... Mondelli, V. (2015). Inflammation and metabolic changes in First Episode Psychosis: Preliminary results from a longitudinal study. Brain Behavior and Immunity, 49, 25–29. DOI: 10.1016/j.bbi.2015.06.004

Vancouver

Russell A, Ciufolini S, Gardner-Sood P, Bonaccorso S, Gaughran F, Dazzan P et al. Inflammation and metabolic changes in First Episode Psychosis: Preliminary results from a longitudinal study. Brain Behavior and Immunity. 2015 Oct;49:25–29. Available from, DOI: 10.1016/j.bbi.2015.06.004

Author

Russell, Alice; Ciufolini, Simone; Gardner-Sood, Poonam; Bonaccorso, Stefania; Gaughran, Fiona; Dazzan, Paola; Pariante, Carmine M; Mondelli, Valeria / Inflammation and metabolic changes in First Episode Psychosis : Preliminary results from a longitudinal study.

In: Brain Behavior and Immunity, Vol. 49, 10.2015, p. 25–29.

Research output: Contribution to journalArticle

Bibtex Download

@article{50b6c94dc95642a48452da287fcaf098,
title = "Inflammation and metabolic changes in First Episode Psychosis: Preliminary results from a longitudinal study",
author = "Alice Russell and Simone Ciufolini and Poonam Gardner-Sood and Stefania Bonaccorso and Fiona Gaughran and Paola Dazzan and Pariante, {Carmine M} and Valeria Mondelli",
note = "Copyright © 2015. Published by Elsevier Inc.",
year = "2015",
month = "10",
doi = "10.1016/j.bbi.2015.06.004",
volume = "49",
pages = "25–29",
journal = "Brain, behavior, and immunity",
issn = "0889-1591",
publisher = "Academic Press Inc.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Inflammation and metabolic changes in First Episode Psychosis

T2 - Brain, behavior, and immunity

AU - Russell,Alice

AU - Ciufolini,Simone

AU - Gardner-Sood,Poonam

AU - Bonaccorso,Stefania

AU - Gaughran,Fiona

AU - Dazzan,Paola

AU - Pariante,Carmine M

AU - Mondelli,Valeria

N1 - Copyright © 2015. Published by Elsevier Inc.

PY - 2015/10

Y1 - 2015/10

N2 - <p>Metabolic abnormalities are commonly observed in patients with psychosis, and may confer greater risk of developing cardiovascular disease later in life. Such abnormalities are associated with inflammation in the general population, and there is increasing evidence for elevated inflammation in patients with first episode psychosis (FEP). The aim of this preliminary study is to examine the effect of changes in inflammation, as measured by high-sensitivity C-reactive protein (hsCRP), on metabolic changes in a three-month longitudinal study in a FEP sample. Fifty-three FEP patients from in- and out-patient services in South London, England, were included in this longitudinal study. Social and clinical data were collected, and fasting blood samples and anthropometric measurements (weight, Body Mass Index (BMI), lipid profile and gluco-metabolic parameters) were obtained at baseline and at three-month follow-up. Correlation analyses showed that those with increases in hsCRP over the three-month period also had increases in triglyceride levels (r = 0.49, p = 0.02). No association was observed with other lipid profile, or gluco-metabolic parameters. Increases in weight and BMI were also associated with increases in triglyceride levels (r = 0.33, p = 0.02; and r = 0.31, p = 0.03, respectively); however, a multiple linear regression analysis found that the effects of inflammation on triglycerides were independent from the effect of changes in weight, and from the baseline inflammatory state. Our preliminary findings suggest that those patients experiencing greater increases in inflammation early on in the course of their illness may be at greater risk of developing short-term metabolic abnormalities, in particular dyslipidaemia, independent of weight-gain. Future work should investigate the use of inflammatory markers to identify patients in greater need of physical health interventions.</p>

AB - <p>Metabolic abnormalities are commonly observed in patients with psychosis, and may confer greater risk of developing cardiovascular disease later in life. Such abnormalities are associated with inflammation in the general population, and there is increasing evidence for elevated inflammation in patients with first episode psychosis (FEP). The aim of this preliminary study is to examine the effect of changes in inflammation, as measured by high-sensitivity C-reactive protein (hsCRP), on metabolic changes in a three-month longitudinal study in a FEP sample. Fifty-three FEP patients from in- and out-patient services in South London, England, were included in this longitudinal study. Social and clinical data were collected, and fasting blood samples and anthropometric measurements (weight, Body Mass Index (BMI), lipid profile and gluco-metabolic parameters) were obtained at baseline and at three-month follow-up. Correlation analyses showed that those with increases in hsCRP over the three-month period also had increases in triglyceride levels (r = 0.49, p = 0.02). No association was observed with other lipid profile, or gluco-metabolic parameters. Increases in weight and BMI were also associated with increases in triglyceride levels (r = 0.33, p = 0.02; and r = 0.31, p = 0.03, respectively); however, a multiple linear regression analysis found that the effects of inflammation on triglycerides were independent from the effect of changes in weight, and from the baseline inflammatory state. Our preliminary findings suggest that those patients experiencing greater increases in inflammation early on in the course of their illness may be at greater risk of developing short-term metabolic abnormalities, in particular dyslipidaemia, independent of weight-gain. Future work should investigate the use of inflammatory markers to identify patients in greater need of physical health interventions.</p>

U2 - 10.1016/j.bbi.2015.06.004

DO - 10.1016/j.bbi.2015.06.004

M3 - Article

VL - 49

SP - 25

EP - 29

JO - Brain, behavior, and immunity

JF - Brain, behavior, and immunity

SN - 0889-1591

ER -

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