Inflammatory biomarker profiles of mental disorders and their relation to clinical, social and lifestyle factors

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119 Citations (Scopus)

Abstract

In the last few decades, mental health research has increasingly provided evidence supporting the role of inflammation in pathogenesis, course and treatment of mental disorders. With such a steep incline of research, resulting in a wealth of emerged findings, it has become difficult to follow developments within the field. The present review sets out to present the recent developments and to give an overview of the inflammatory profiles of depression, psychosis and bipolar disorder, as well as variations within these disorders. Moreover, mediating factors such as social environment and childhood experience are discussed, both in terms of their potential in elucidating the complex interface between the inflammation and other closely related biological systems, as well as the possibly confounding impact of various lifestyle factors. Whilst many issues in this fascinating area of research remain to be fully understood and elaborated, all current evidence suggests that inflammation plays a key role in mental disorders and may open up novel avenues for clinical treatment.

Original languageEnglish
Pages (from-to)841-849
Number of pages9
JournalSocial Psychiatry and Psychiatric Epidemiology
Volume49
Issue number6
DOIs
Publication statusPublished - 1 Jun 2014

Keywords

  • Bipolar disorder
  • Cytokine
  • Depression
  • Inflammation
  • Interleukin
  • Psychosis

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