Inflammatory Memory in Psoriasis: From Remission to Recurrence

Luc Francis; Francesca Capon; Catherine H Smith; Muzlifah Haniffa; Satveer K Mahil

doi:10.1016/j.jaci.2024.05.008

Inflammatory Memory in Psoriasis: From Remission to Recurrence

Luc Francis, Francesca Capon, Catherine H Smith, Muzlifah Haniffa, Satveer K Mahil

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

The routine use of targeted systemic immunomodulatory therapies has transformed outcomes for people with severe psoriasis, with skin clearance (clinical remission) rates up to 60% at 1 year of biologic treatment. However, psoriasis may recur following drug withdrawal, and as a result, patients tend to continue receiving costly treatment indefinitely. Here, we review research into the “inflammatory memory” in resolved psoriasis skin and the potential mechanisms leading to psoriasis recurrence following drug withdrawal. Research has implicated immune cells such as tissue resident memory T cells, Langerhans cells, and dermal dendritic cells, and there is growing interest in keratinocytes and fibroblasts. A better understanding of the interactions between these cell populations, enabled by single cell technologies, will help to elucidate the events underpinning the shift from remission to recurrence. This may inform the development of personalized strategies for sustaining remission while reducing long-term drug burden.

Original language	English
Pages (from-to)	42-50
Number of pages	9
Journal	Journal of Allergy and Clinical Immunology
Volume	154
Issue number	1
DOIs	https://doi.org/10.1016/j.jaci.2024.05.008
Publication status	E-pub ahead of print - 16 May 2024

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10.1016/j.jaci.2024.05.008

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title = "Inflammatory Memory in Psoriasis: From Remission to Recurrence",

abstract = "The routine use of targeted systemic immunomodulatory therapies has transformed outcomes for people with severe psoriasis, with skin clearance (clinical remission) rates up to 60% at 1 year of biologic treatment. However, psoriasis may recur following drug withdrawal, and as a result, patients tend to continue receiving costly treatment indefinitely. Here, we review research into the “inflammatory memory” in resolved psoriasis skin and the potential mechanisms leading to psoriasis recurrence following drug withdrawal. Research has implicated immune cells such as tissue resident memory T cells, Langerhans cells, and dermal dendritic cells, and there is growing interest in keratinocytes and fibroblasts. A better understanding of the interactions between these cell populations, enabled by single cell technologies, will help to elucidate the events underpinning the shift from remission to recurrence. This may inform the development of personalized strategies for sustaining remission while reducing long-term drug burden.",

author = "Luc Francis and Francesca Capon and Smith, {Catherine H} and Muzlifah Haniffa and Mahil, {Satveer K}",

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T1 - Inflammatory Memory in Psoriasis

T2 - From Remission to Recurrence

AU - Francis, Luc

AU - Capon, Francesca

AU - Smith, Catherine H

AU - Haniffa, Muzlifah

AU - Mahil, Satveer K

PY - 2024/5/16

Y1 - 2024/5/16

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Inflammatory Memory in Psoriasis: From Remission to Recurrence

Abstract

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