Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins

TY - JOUR

T1 - Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins

AU - Makowski, Marcus R.

AU - Jansen, Christian H P

AU - Ebersberger, Ullrich

AU - Schaeffter, Tobias

AU - Razavi, Reza

AU - Mangino, Massimo

AU - Spector, Tim

AU - Botnar, Rene M.

AU - Greil, Gerald

PY - 2016/10/14

Y1 - 2016/10/14

N2 - Objectives: The aim of this study was to investigate the impact of BMI on late gadolinium enhancement (LGE) of the coronary artery wall in identical monozygous twins discordant for BMI. Coronary LGE represents a useful parameter for the detection and quantification of atherosclerotic coronary vessel wall disease. Methods: Thirteen monozygote female twin pairs (n = 26) with significantly different BMIs (>1.6 kg/m2) were recruited out of >10,000 twin pairs (TwinsUK Registry). A coronary 3D-T2prep-TFE MR angiogram and 3D-IR-TFE vessel wall scan were performed prior to and following the administration of 0.2 mmol/kg of Gd-DTPA on a 1.5 T MR scanner. The number of enhancing coronary segments and contrast to noise ratios (CNRs) of the coronary wall were quantified. Results: An increase in BMI was associated with an increased number of enhancing coronary segments (5.3 ± 1.5 vs. 3.5 ± 1.6, p <0.0001) and increased coronary wall enhancement (6.1 ± 1.1 vs. 4.8 ± 0.9, p = 0.0027) compared to matched twins with lower BMI. Conclusions: This study in monozygous twins indicates that acquired factors predisposing to obesity, including lifestyle and environmental factors, result in increased LGE of the coronary arteries, potentially reflecting an increase in coronary atherosclerosis in this female study population. Key points: • BMI-discordant twins allow the investigation of the influence of lifestyle factors independent from genetic confounders.• Only thirteen obesity-discordant twins were identified underlining the strong genetic component of BMI.• In female twins, a BMI increase is associated with increased coronary late gadolinium enhancement.• Increased late gadolinium enhancement in the coronary vessel wall potentially reflects increased atherosclerosis.

AB - Objectives: The aim of this study was to investigate the impact of BMI on late gadolinium enhancement (LGE) of the coronary artery wall in identical monozygous twins discordant for BMI. Coronary LGE represents a useful parameter for the detection and quantification of atherosclerotic coronary vessel wall disease. Methods: Thirteen monozygote female twin pairs (n = 26) with significantly different BMIs (>1.6 kg/m2) were recruited out of >10,000 twin pairs (TwinsUK Registry). A coronary 3D-T2prep-TFE MR angiogram and 3D-IR-TFE vessel wall scan were performed prior to and following the administration of 0.2 mmol/kg of Gd-DTPA on a 1.5 T MR scanner. The number of enhancing coronary segments and contrast to noise ratios (CNRs) of the coronary wall were quantified. Results: An increase in BMI was associated with an increased number of enhancing coronary segments (5.3 ± 1.5 vs. 3.5 ± 1.6, p <0.0001) and increased coronary wall enhancement (6.1 ± 1.1 vs. 4.8 ± 0.9, p = 0.0027) compared to matched twins with lower BMI. Conclusions: This study in monozygous twins indicates that acquired factors predisposing to obesity, including lifestyle and environmental factors, result in increased LGE of the coronary arteries, potentially reflecting an increase in coronary atherosclerosis in this female study population. Key points: • BMI-discordant twins allow the investigation of the influence of lifestyle factors independent from genetic confounders.• Only thirteen obesity-discordant twins were identified underlining the strong genetic component of BMI.• In female twins, a BMI increase is associated with increased coronary late gadolinium enhancement.• Increased late gadolinium enhancement in the coronary vessel wall potentially reflects increased atherosclerosis.

KW - 3D-IR-TFE

KW - Coronary

KW - MRI

KW - Twin

KW - Vessel wall scan

UR - http://www.scopus.com/inward/record.url?scp=84991110334&partnerID=8YFLogxK

U2 - 10.1007/s00330-016-4616-8

DO - 10.1007/s00330-016-4616-8

M3 - Article

AN - SCOPUS:84991110334

SN - 0938-7994

SP - 1

EP - 7

JO - European Radiology

JF - European Radiology

ER -