Influence of bronchopulmonary dysplasia on lung function in adolescents who were born extremely prematurely

TY - JOUR

T1 - Influence of bronchopulmonary dysplasia on lung function in adolescents who were born extremely prematurely

AU - Harris, Christopher

AU - Morris, Samuel

AU - Lunt, Alan

AU - Peacock, Janet

AU - Greenough, Anne

N1 - Funding Information: Alan Lunt was instrumental in supporting the many studies relating to the UKOS cohort, sadly he died in 2021. We thank Deirdre Gibbons for secretarial assistance. This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. Publisher Copyright: © 2022 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.

PY - 2022/12

Y1 - 2022/12

N2 - Objectives: To assess if a previous diagnosis of bronchopulmonary dysplasia (BPD) was associated with poorer lung function at 16 to 19 years of age, regardless of whether postnatal corticosteroids had been administered. Working Hypothesis: Infants with BPD will have poorer lung function at 16 to 19 years of age. Study Design: Prospective follow-up study. Patient-Subject Selection: One hundred and sixty-one participants aged between 16 and 19 years who were born at less than 29 weeks of gestation; 87 had had BPD. Methodology: Lung function was assessed by spirometry (FEV1, FVC, FEV1/FVC, FEF75, FEF50, FEF25, FEF25–75, PEF), impulse oscillometry (R5Hz and R20Hz), plethysmography (FRCpleth, TLCpleth, RVpleth), diffusion capacity of the lungs for carbon monoxide (DLCO, DLCO/VA) and lung clearance index (LCI). Questionnaires were used to quantify respiratory symptoms and a shuttle sprint test to assess exercise capacity. Results: At 16 to 19 years, those who had had a diagnosis of BPD had poorer airway function (FEV1, FEF75, FEF50, FEF25–75) compared to those without. FVC and DLCO were also poorer in those who had BPD. Those differences remained significant after adjusting for sex, gestational age, and maternal smoking. When excluding those who had received postnatal corticosteroids, differences remained significant in FEV1, FVC, and FEF75. There were no significant differences in exercise capacity or respiratory symptoms between those with and without BPD. Conclusions: In adolescents and young adults born prematurely, those who had BPD had poorer lung function compared to those without, regardless of whether they had received postnatal corticosteroids.

AB - Objectives: To assess if a previous diagnosis of bronchopulmonary dysplasia (BPD) was associated with poorer lung function at 16 to 19 years of age, regardless of whether postnatal corticosteroids had been administered. Working Hypothesis: Infants with BPD will have poorer lung function at 16 to 19 years of age. Study Design: Prospective follow-up study. Patient-Subject Selection: One hundred and sixty-one participants aged between 16 and 19 years who were born at less than 29 weeks of gestation; 87 had had BPD. Methodology: Lung function was assessed by spirometry (FEV1, FVC, FEV1/FVC, FEF75, FEF50, FEF25, FEF25–75, PEF), impulse oscillometry (R5Hz and R20Hz), plethysmography (FRCpleth, TLCpleth, RVpleth), diffusion capacity of the lungs for carbon monoxide (DLCO, DLCO/VA) and lung clearance index (LCI). Questionnaires were used to quantify respiratory symptoms and a shuttle sprint test to assess exercise capacity. Results: At 16 to 19 years, those who had had a diagnosis of BPD had poorer airway function (FEV1, FEF75, FEF50, FEF25–75) compared to those without. FVC and DLCO were also poorer in those who had BPD. Those differences remained significant after adjusting for sex, gestational age, and maternal smoking. When excluding those who had received postnatal corticosteroids, differences remained significant in FEV1, FVC, and FEF75. There were no significant differences in exercise capacity or respiratory symptoms between those with and without BPD. Conclusions: In adolescents and young adults born prematurely, those who had BPD had poorer lung function compared to those without, regardless of whether they had received postnatal corticosteroids.

KW - Chronic lung disease

KW - postnatal corticosteroids

KW - young adults

UR - https://www.scopus.com/pages/publications/85138704803

U2 - 10.1002/ppul.26151

DO - 10.1002/ppul.26151

M3 - Article

C2 - 36098237

AN - SCOPUS:85138704803

SN - 8755-6863

VL - 57

SP - 3151

EP - 3157

JO - Pediatric pulmonology

JF - Pediatric pulmonology

IS - 12

ER -