Influence of the precipitation temperature on properties of nanohydroxyapatite powder for the fabrication of highly porous bone scaffolds

TY - JOUR

T1 - Influence of the precipitation temperature on properties of nanohydroxyapatite powder for the fabrication of highly porous bone scaffolds

AU - Parisi, Cristian

AU - Gervaso, Francesca

AU - Scalera, Francesca

AU - Kunjalukkal Padmanabhan, Sanosh

AU - Nobile, Concetta

AU - Cozzoli, Davide

AU - Di-Silvio, Lucy

AU - Sannino, Alessandro

PY - 2014

Y1 - 2014

N2 - The aim of the present work is to study the influence of the precipitation temperature in the synthesis of nanohydroxyapatite (n-HAp) on the properties of the resulting n-HAp powder for the fabrication of highly porous scaffolds for bone tissue engineering. The n-HAp powder was obtained by a wet precipitation technique starting from calcium nitrate tetrahydrate (Ca (NO3)2*4H2O) and phosphoric acid (H3PO4) at different temperatures: 10°C, 37°C and 50°C. Highly porous scaffolds were fabricated using the three different powders by the sponge replica method and sintering at 1300°C. Combined X-ray diffraction (XRD) and transmission electron microscopy (TEM) analyses on powders indicated that on increasing the precipitation temperature the formation of pure n-HAp is accelerated, without significant changes in particles morphology and size. Scaffolds characterized by high porosity (89%) and good compressive strength (0.53 MPa for n-HAp prepared at 37°C) were obtained. XRD analyses on sintered n-HAp confirmed the thermal stability of the material. Therefore, the as-synthesized n-HAp powder can be successfully used for the fabrication of highly porous scaffolds as bone substitutes.

AB - The aim of the present work is to study the influence of the precipitation temperature in the synthesis of nanohydroxyapatite (n-HAp) on the properties of the resulting n-HAp powder for the fabrication of highly porous scaffolds for bone tissue engineering. The n-HAp powder was obtained by a wet precipitation technique starting from calcium nitrate tetrahydrate (Ca (NO3)2*4H2O) and phosphoric acid (H3PO4) at different temperatures: 10°C, 37°C and 50°C. Highly porous scaffolds were fabricated using the three different powders by the sponge replica method and sintering at 1300°C. Combined X-ray diffraction (XRD) and transmission electron microscopy (TEM) analyses on powders indicated that on increasing the precipitation temperature the formation of pure n-HAp is accelerated, without significant changes in particles morphology and size. Scaffolds characterized by high porosity (89%) and good compressive strength (0.53 MPa for n-HAp prepared at 37°C) were obtained. XRD analyses on sintered n-HAp confirmed the thermal stability of the material. Therefore, the as-synthesized n-HAp powder can be successfully used for the fabrication of highly porous scaffolds as bone substitutes.

U2 - 10.4028/www.scientific.net/KEM.587.27

DO - 10.4028/www.scientific.net/KEM.587.27

M3 - Article

SN - 1013-9826

VL - 587

SP - 27

EP - 32

JO - KEY ENGINEERING MATERIALS

JF - KEY ENGINEERING MATERIALS

IS - N/A

M1 - N/A

ER -