Influenza burden, prevention, and treatment in asthma-A scoping review by the EAACI Influenza in asthma task force

TY - JOUR

T1 - Influenza burden, prevention, and treatment in asthma-A scoping review by the EAACI Influenza in asthma task force

AU - Schwarze, J.

AU - Openshaw, P.

AU - Jha, A.

AU - del Giacco, S. R.

AU - Firinu, D.

AU - Tsilochristou, O.

AU - Roberts, G.

AU - Selby, A.

AU - Akdis, C.

AU - Agache, I.

AU - Custovic, A.

AU - Heffler, E.

AU - Pinna, G.

AU - Khaitov, M.

AU - Nikonova, A.

AU - Papadopoulos, N.

AU - Akhlaq, A.

AU - Nurmatov, U.

AU - Renz, H.

AU - Sheikh, A.

AU - Skevaki, C.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness, and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma. The strongest evidence of an association was seen in studies of children. Countries in the European Union currently recommend influenza vaccination of adults with asthma; however, coverage varied between regions. Coverage was lower among children with asthma. Limited data suggest that good seroprotection and seroconversion can be achieved in both children and adults with asthma and that vaccination confers a degree of protection against influenza illness and asthma-related morbidity to children with asthma. There were insufficient data to determine efficacy in adults. Overall, influenza vaccines appeared to be safe for people with asthma. We identify knowledge gaps and make recommendations on future research needs in relation to influenza in patients with asthma.

AB - To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness, and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma. The strongest evidence of an association was seen in studies of children. Countries in the European Union currently recommend influenza vaccination of adults with asthma; however, coverage varied between regions. Coverage was lower among children with asthma. Limited data suggest that good seroprotection and seroconversion can be achieved in both children and adults with asthma and that vaccination confers a degree of protection against influenza illness and asthma-related morbidity to children with asthma. There were insufficient data to determine efficacy in adults. Overall, influenza vaccines appeared to be safe for people with asthma. We identify knowledge gaps and make recommendations on future research needs in relation to influenza in patients with asthma.

KW - antivirals

KW - heath care utilization

KW - respiratory

KW - vaccination

KW - viral infection

UR - http://www.scopus.com/inward/record.url?scp=85041044559&partnerID=8YFLogxK

U2 - 10.1111/all.13333

DO - 10.1111/all.13333

M3 - Review article

AN - SCOPUS:85041044559

SN - 0105-4538

VL - 73

SP - 1151

EP - 1181

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 6

ER -