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Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors

Research output: Contribution to journalArticle

A.T. Kunzmann, M. Canadas Garre, A.P. Thrift, Ú.C. McMenamin, B.T. Johnston, C.R. Cardwell, L.A. Anderson, A.D. Spence, J. Lagergren, S.-H. Xie, L.J. Smyth, A.J. McKnight, H.G. Coleman

Original languageEnglish
JournalGastroenterology
Early online date19 Sep 2018
DOIs
Accepted/In press13 Sep 2018
E-pub ahead of print19 Sep 2018

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Abstract

We previously developed a tool that identified individuals who later developed esophageal adenocarcinoma (EAC; based on age, sex, body mass index, smoking status, and prior esophageal conditions) with an area under the curve of 0.80. In this study, we collected data from 329,463 individuals in the UK Biobank cohort who were tested for genetic susceptibility to EAC (a polygenic risk score based on 18 recognized genetic variants). We found that after inclusion of this genetic information, the area under the curve for identification of individuals who developed EAC remained at 0.80. Testing for genetic variants associated with EAC therefore seems unlikely to improve identification of individuals at risk of EAC.

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