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Inhaled nitric oxide for preventing prematurity-related bronchopulmonary dysplasia: seven-year follow-up of the EUNO trial: Long-term effects of inhaled nitric oxide

Research output: Contribution to journalArticle

Anne Greenough, Fabrice Decobert, David Field, Mikko Hallman, Helmut Hummler, Baldvin Jonsson, Manuel Sanchez Luna, Bart Van Overmeire, Virgilio Carnielli, Jim Potenziano,, Jean-Christophe Mercier

Original languageEnglish
JournalJournal of Perinatal Medicine


  • EUNO paper

    EUNO_paper.doc, 106 KB, application/msword

    Uploaded date:02 Oct 2020

    Version:Accepted author manuscript

King's Authors


Background: Most studies of inhaled nitric oxide (iNO) for prevention of bronchopulmonary dysplasia (BPD) in premature infants have focused on short term mortality and morbidity. Our aim was to determine the long-term effects of iNO.
Methods: A seven-year follow-up was undertaken of infants entered into a multicenter, double-blind, randomized, placebo-controlled trial of iNO for prevention of BPD in premature infants born between 24 and 28 weeks plus 6 days of gestation. At seven years, survival and hospital admissions since the two-year follow-up, home oxygen therapy in the past year, therapies used in the previous month and growth assessments were determined. Questionnaires were used to compare general health, well-being, and quality of life.
Results: Three hundred and five children were assessed. No deaths were reported. Rates of hospitalization for respiratory problems (6.6% vs 10.5%, iNO and placebo group, respectively) and use of respiratory medications (6.6% vs 9.2%) were similar. Two patients who received iNO and one who received placebo had received home oxygen therapy. There were no significant differences in any questionnaire-documented health outcomes.
Conclusions: iNO for prevention of BPD in very premature infants with respiratory distress did not result in long-term benefits or adverse long-term sequelae. In the light of current evidence, routine use of iNO cannot be recommended for prevention of BPD in preterm infants.

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