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Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class

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Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class. / Dodev, T. S.; Bowen, H.; Shamji, M. H.; Bax, H. J.; Beavil, A. J.; McDonnell, J. M.; Durham, S. R.; Sutton, B. J.; Gould, H. J.; James, Louisa K.

In: Allergy, Vol. 70, No. 6, 01.06.2015, p. 720-724.

Research output: Contribution to journalArticle

Harvard

Dodev, TS, Bowen, H, Shamji, MH, Bax, HJ, Beavil, AJ, McDonnell, JM, Durham, SR, Sutton, BJ, Gould, HJ & James, LK 2015, 'Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class', Allergy, vol. 70, no. 6, pp. 720-724. https://doi.org/10.1111/all.12607

APA

Dodev, T. S., Bowen, H., Shamji, M. H., Bax, H. J., Beavil, A. J., McDonnell, J. M., ... James, L. K. (2015). Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class. Allergy, 70(6), 720-724. https://doi.org/10.1111/all.12607

Vancouver

Dodev TS, Bowen H, Shamji MH, Bax HJ, Beavil AJ, McDonnell JM et al. Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class. Allergy. 2015 Jun 1;70(6):720-724. https://doi.org/10.1111/all.12607

Author

Dodev, T. S. ; Bowen, H. ; Shamji, M. H. ; Bax, H. J. ; Beavil, A. J. ; McDonnell, J. M. ; Durham, S. R. ; Sutton, B. J. ; Gould, H. J. ; James, Louisa K. / Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class. In: Allergy. 2015 ; Vol. 70, No. 6. pp. 720-724.

Bibtex Download

@article{c4e4511e253645a69175646585456cbe,
title = "Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class",
abstract = "Abstract IgG4 purified from patients undergoing specific allergen immunotherapy inhibits the activities of the serum IgE in in vitro assays and is thought to reduce the symptoms of the disease. However, it is not known whether this is related to an intrinsic property of this subclass or only the allergen specificity. We tested the hypothesis that allergen specificity is the critical determinant for this activity using a panel of antibodies with identical specificity but different subclasses. The different antibodies were all able to inhibit the activity of IgE to the same extent. We demonstrate that specificity is the dominant factor determining the ability of an antibody to block allergen-dependent IgE activity.",
keywords = "allergen, antibody, immunotherapy, isotype, specificity",
author = "Dodev, {T. S.} and H. Bowen and Shamji, {M. H.} and Bax, {H. J.} and Beavil, {A. J.} and McDonnell, {J. M.} and Durham, {S. R.} and Sutton, {B. J.} and Gould, {H. J.} and James, {Louisa K.}",
year = "2015",
month = "6",
day = "1",
doi = "10.1111/all.12607",
language = "English",
volume = "70",
pages = "720--724",
journal = "Allergy",
issn = "0105-4538",
publisher = "Blackwell Publishing",
number = "6",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class

AU - Dodev, T. S.

AU - Bowen, H.

AU - Shamji, M. H.

AU - Bax, H. J.

AU - Beavil, A. J.

AU - McDonnell, J. M.

AU - Durham, S. R.

AU - Sutton, B. J.

AU - Gould, H. J.

AU - James, Louisa K.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Abstract IgG4 purified from patients undergoing specific allergen immunotherapy inhibits the activities of the serum IgE in in vitro assays and is thought to reduce the symptoms of the disease. However, it is not known whether this is related to an intrinsic property of this subclass or only the allergen specificity. We tested the hypothesis that allergen specificity is the critical determinant for this activity using a panel of antibodies with identical specificity but different subclasses. The different antibodies were all able to inhibit the activity of IgE to the same extent. We demonstrate that specificity is the dominant factor determining the ability of an antibody to block allergen-dependent IgE activity.

AB - Abstract IgG4 purified from patients undergoing specific allergen immunotherapy inhibits the activities of the serum IgE in in vitro assays and is thought to reduce the symptoms of the disease. However, it is not known whether this is related to an intrinsic property of this subclass or only the allergen specificity. We tested the hypothesis that allergen specificity is the critical determinant for this activity using a panel of antibodies with identical specificity but different subclasses. The different antibodies were all able to inhibit the activity of IgE to the same extent. We demonstrate that specificity is the dominant factor determining the ability of an antibody to block allergen-dependent IgE activity.

KW - allergen

KW - antibody

KW - immunotherapy

KW - isotype

KW - specificity

UR - http://www.scopus.com/inward/record.url?scp=84929930913&partnerID=8YFLogxK

U2 - 10.1111/all.12607

DO - 10.1111/all.12607

M3 - Article

AN - SCOPUS:84929930913

VL - 70

SP - 720

EP - 724

JO - Allergy

JF - Allergy

SN - 0105-4538

IS - 6

ER -

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