Initial experience of cardiac T1ρ mapping at 0.55 T: Continuous wave versus adiabatic spin-lock preparation pulses.

Dongyue Si; Michael G Crabb; Simon J Littlewood; Karl P Kunze; Juliet Varghese; Katherine Binzel; Mahmood Khan; Orlando P Simonetti; Claudia Prieto; René M Botnar

doi:10.1002/mrm.30582

Initial experience of cardiac T₁ρ mapping at 0.55 T: Continuous wave versus adiabatic spin-lock preparation pulses.

Dongyue Si, Michael G Crabb, Simon J Littlewood, Karl P Kunze, Juliet Varghese, Katherine Binzel, Mahmood Khan, Orlando P Simonetti, Claudia Prieto, René M Botnar

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Abstract

Purpose: To propose and validate a cardiac T ₁ρ mapping sequence at 0.55 T comparing continuous-wave and adiabatic spin-lock (SL) preparation pulses. Methods: The proposed 2D sequence acquires four single-shot balanced SSFP readout images with differing contrasts in a single breath-hold. The first three images are prepared with T ₁ρ preparation pulses with different durations, while the last image uses a saturation pulse immediately before data acquisition. The T ₁ρ map is calculated using a 3-parameter fitting method. Bloch equation simulations were performed to optimize the parameters of the adiabatic-SL pulses. Phantom studies and in vivo experiments in 10 healthy volunteers, a porcine myocardial infarction model, and a patient with suspected hypertrophic cardiomyopathy were performed to validate the performance of the proposed adiabatic T ₁ρ (T ₁ρ _Ad) mapping in comparison with conventional continuous-wave T ₁ρ (T ₁ρ _CW) mapping. Results: The adiabatic-SL pulse with simulation-optimized parameters demonstrated robust performance despite B ₀ and B ₁ field inhomogeneities. Phantom T ₁ρ _CW and T ₁ρ _Ad mapping exhibited comparable precision. In vivo experiments on healthy volunteers showed that myocardial T ₁ρ _Ad is higher than T ₁ρ _CW (106.1 ± 7.1 vs. 47.0 ± 5.1 ms, p < 0.01) with better precision (11.4% ± 2.6% vs. 14.5% ± 2.1%, p < 0.01) and less spatial variation (10.9% ± 3.0% vs. 14.4% ± 3.4%, p < 0.01). Both T ₁ρ _CW and T ₁ρ _Ad mapping agreed with late gadolinium enhancement findings in the porcine model and the patient, and exhibited improved contrast compared to T ₁ and T ₂ mapping. Conclusion: Both T ₁ρ _CW and T ₁ρ _Ad are promising for non-contrast detection of various cardiomyopathies at 0.55 T, but T ₁ρ _Ad demonstrates better spatial uniformity than T ₁ρ _CW.

Original language	English
Journal	Magnetic Resonance in Medicine
Early online date	20 May 2025
DOIs	https://doi.org/10.1002/mrm.30582
Publication status	E-pub ahead of print - 20 May 2025

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Magnetic Resonance in Med - 2025 - Si - Initial experience of cardiac T1 mapping at 0 55 T Continuous wave versus (1)Final published version, 3.18 MBLicence: CC BY

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@article{b3d6818c4fdd4bf1bf2b1308ab3eb560,

title = "Initial experience of cardiac T1ρ mapping at 0.55 T: Continuous wave versus adiabatic spin-lock preparation pulses.",

abstract = "Purpose: To propose and validate a cardiac T 1ρ mapping sequence at 0.55 T comparing continuous-wave and adiabatic spin-lock (SL) preparation pulses. Methods: The proposed 2D sequence acquires four single-shot balanced SSFP readout images with differing contrasts in a single breath-hold. The first three images are prepared with T 1ρ preparation pulses with different durations, while the last image uses a saturation pulse immediately before data acquisition. The T 1ρ map is calculated using a 3-parameter fitting method. Bloch equation simulations were performed to optimize the parameters of the adiabatic-SL pulses. Phantom studies and in vivo experiments in 10 healthy volunteers, a porcine myocardial infarction model, and a patient with suspected hypertrophic cardiomyopathy were performed to validate the performance of the proposed adiabatic T 1ρ (T 1ρ Ad) mapping in comparison with conventional continuous-wave T 1ρ (T 1ρ CW) mapping. Results: The adiabatic-SL pulse with simulation-optimized parameters demonstrated robust performance despite B 0 and B 1 field inhomogeneities. Phantom T 1ρ CW and T 1ρ Ad mapping exhibited comparable precision. In vivo experiments on healthy volunteers showed that myocardial T 1ρ Ad is higher than T 1ρ CW (106.1 ± 7.1 vs. 47.0 ± 5.1 ms, p < 0.01) with better precision (11.4% ± 2.6% vs. 14.5% ± 2.1%, p < 0.01) and less spatial variation (10.9% ± 3.0% vs. 14.4% ± 3.4%, p < 0.01). Both T 1ρ CW and T 1ρ Ad mapping agreed with late gadolinium enhancement findings in the porcine model and the patient, and exhibited improved contrast compared to T 1 and T 2 mapping. Conclusion: Both T 1ρ CW and T 1ρ Ad are promising for non-contrast detection of various cardiomyopathies at 0.55 T, but T 1ρ Ad demonstrates better spatial uniformity than T 1ρ CW.",

author = "Dongyue Si and Crabb, {Michael G} and Littlewood, {Simon J} and Kunze, {Karl P} and Juliet Varghese and Katherine Binzel and Mahmood Khan and Simonetti, {Orlando P} and Claudia Prieto and Botnar, {Ren{\'e} M}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.",

year = "2025",

month = may,

day = "20",

doi = "10.1002/mrm.30582",

language = "English",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "WILEY-BLACKWELL",

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TY - JOUR

T1 - Initial experience of cardiac T1ρ mapping at 0.55 T

T2 - Continuous wave versus adiabatic spin-lock preparation pulses.

AU - Si, Dongyue

AU - Crabb, Michael G

AU - Littlewood, Simon J

AU - Kunze, Karl P

AU - Varghese, Juliet

AU - Binzel, Katherine

AU - Khan, Mahmood

AU - Simonetti, Orlando P

AU - Prieto, Claudia

AU - Botnar, René M

PY - 2025/5/20

Y1 - 2025/5/20

N2 - Purpose: To propose and validate a cardiac T 1ρ mapping sequence at 0.55 T comparing continuous-wave and adiabatic spin-lock (SL) preparation pulses. Methods: The proposed 2D sequence acquires four single-shot balanced SSFP readout images with differing contrasts in a single breath-hold. The first three images are prepared with T 1ρ preparation pulses with different durations, while the last image uses a saturation pulse immediately before data acquisition. The T 1ρ map is calculated using a 3-parameter fitting method. Bloch equation simulations were performed to optimize the parameters of the adiabatic-SL pulses. Phantom studies and in vivo experiments in 10 healthy volunteers, a porcine myocardial infarction model, and a patient with suspected hypertrophic cardiomyopathy were performed to validate the performance of the proposed adiabatic T 1ρ (T 1ρ Ad) mapping in comparison with conventional continuous-wave T 1ρ (T 1ρ CW) mapping. Results: The adiabatic-SL pulse with simulation-optimized parameters demonstrated robust performance despite B 0 and B 1 field inhomogeneities. Phantom T 1ρ CW and T 1ρ Ad mapping exhibited comparable precision. In vivo experiments on healthy volunteers showed that myocardial T 1ρ Ad is higher than T 1ρ CW (106.1 ± 7.1 vs. 47.0 ± 5.1 ms, p < 0.01) with better precision (11.4% ± 2.6% vs. 14.5% ± 2.1%, p < 0.01) and less spatial variation (10.9% ± 3.0% vs. 14.4% ± 3.4%, p < 0.01). Both T 1ρ CW and T 1ρ Ad mapping agreed with late gadolinium enhancement findings in the porcine model and the patient, and exhibited improved contrast compared to T 1 and T 2 mapping. Conclusion: Both T 1ρ CW and T 1ρ Ad are promising for non-contrast detection of various cardiomyopathies at 0.55 T, but T 1ρ Ad demonstrates better spatial uniformity than T 1ρ CW.

AB - Purpose: To propose and validate a cardiac T 1ρ mapping sequence at 0.55 T comparing continuous-wave and adiabatic spin-lock (SL) preparation pulses. Methods: The proposed 2D sequence acquires four single-shot balanced SSFP readout images with differing contrasts in a single breath-hold. The first three images are prepared with T 1ρ preparation pulses with different durations, while the last image uses a saturation pulse immediately before data acquisition. The T 1ρ map is calculated using a 3-parameter fitting method. Bloch equation simulations were performed to optimize the parameters of the adiabatic-SL pulses. Phantom studies and in vivo experiments in 10 healthy volunteers, a porcine myocardial infarction model, and a patient with suspected hypertrophic cardiomyopathy were performed to validate the performance of the proposed adiabatic T 1ρ (T 1ρ Ad) mapping in comparison with conventional continuous-wave T 1ρ (T 1ρ CW) mapping. Results: The adiabatic-SL pulse with simulation-optimized parameters demonstrated robust performance despite B 0 and B 1 field inhomogeneities. Phantom T 1ρ CW and T 1ρ Ad mapping exhibited comparable precision. In vivo experiments on healthy volunteers showed that myocardial T 1ρ Ad is higher than T 1ρ CW (106.1 ± 7.1 vs. 47.0 ± 5.1 ms, p < 0.01) with better precision (11.4% ± 2.6% vs. 14.5% ± 2.1%, p < 0.01) and less spatial variation (10.9% ± 3.0% vs. 14.4% ± 3.4%, p < 0.01). Both T 1ρ CW and T 1ρ Ad mapping agreed with late gadolinium enhancement findings in the porcine model and the patient, and exhibited improved contrast compared to T 1 and T 2 mapping. Conclusion: Both T 1ρ CW and T 1ρ Ad are promising for non-contrast detection of various cardiomyopathies at 0.55 T, but T 1ρ Ad demonstrates better spatial uniformity than T 1ρ CW.

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U2 - 10.1002/mrm.30582

DO - 10.1002/mrm.30582

M3 - Article

C2 - 40391626

SN - 0740-3194

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

ER -

Initial experience of cardiac T₁ρ mapping at 0.55 T: Continuous wave versus adiabatic spin-lock preparation pulses.

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