Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness

TY - JOUR

T1 - Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness

AU - Wencker, Melanie

AU - Turchinovich, Gleb

AU - DiMarco Barros, Rafael

AU - Deban, Livija

AU - Jandke, Anett

AU - Cope, Andrew

AU - Hayday, Adrian

PY - 2014/1

Y1 - 2014/1

N2 - The subclassification of immunology into innate and adaptive immunity is challenged by innate-like T lymphocytes that use innate receptors to respond rapidly to stress despite expressing T cell antigen receptors (TCRs), a hallmark of adaptive immunity. In studies that explain how such cells can straddle innate and adaptive immunity, we found that signaling via antigen receptors, whose conventional role is to facilitate clonal T cell activation, was critical for the development of innate-like T cells but then was rapidly attenuated, which accommodated the cells' innate responsiveness. These findings permitted the identification of a previously unknown innate-like T cell subset and indicate that T cell hyporesponsiveness, a state traditionally linked to tolerance, may be fundamental to T cells entering the innate compartment and thereby providing lymphoid stress surveillance.

AB - The subclassification of immunology into innate and adaptive immunity is challenged by innate-like T lymphocytes that use innate receptors to respond rapidly to stress despite expressing T cell antigen receptors (TCRs), a hallmark of adaptive immunity. In studies that explain how such cells can straddle innate and adaptive immunity, we found that signaling via antigen receptors, whose conventional role is to facilitate clonal T cell activation, was critical for the development of innate-like T cells but then was rapidly attenuated, which accommodated the cells' innate responsiveness. These findings permitted the identification of a previously unknown innate-like T cell subset and indicate that T cell hyporesponsiveness, a state traditionally linked to tolerance, may be fundamental to T cells entering the innate compartment and thereby providing lymphoid stress surveillance.

U2 - 10.1038/ni.2773

DO - 10.1038/ni.2773

M3 - Article

SN - 1529-2908

VL - 15

SP - 80

EP - 87

JO - Nature Immunology

JF - Nature Immunology

IS - 1

ER -