Inorganic nitrate and the cardiovascular system

V Kapil; A J Webb; A Ahluwalia

doi:10.1136/hrt.2009.180372

Inorganic nitrate and the cardiovascular system

V Kapil, A J Webb, A Ahluwalia

Queen Mary University of London

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Fruit and vegetable-rich diets reduce blood pressure and risk of ischaemic stroke and ischaemic heart disease. While the cardioprotective effects of a fruit and vegetable-rich diet are unequivocal, the exact mechanisms of this effect remain uncertain. Recent evidence has highlighted the possibility that dietary nitrate, an inorganic anion found in large quantities in vegetables (particularly green leafy vegetables), may have a part to play. This beneficial activity lies in the processing in vivo of nitrate to nitrite and thence to the pleiotropic molecule nitric oxide. In this review, recent preclinical and clinical evidence identifying the mechanisms involved in nitrate bioactivity, and the evidence supporting the potential utility of exploitation of this pathway for the prevention and/or treatment of cardiovascular diseases are discussed.

Original language	English
Pages (from-to)	1703-1709
Number of pages	7
Journal	Heart
Volume	96
Issue number	21
DOIs	https://doi.org/10.1136/hrt.2009.180372
Publication status	Published - Nov 2010

Keywords

Animals
Cardiovascular Diseases
Diet
Fruit
Humans
Hypercholesterolemia
Hypertension
Mice
Myocardial Infarction
Nitrates
Nitric Oxide
Oxygen Consumption
Rats
Vegetables

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/hrt.2009.180372

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abstract = "Fruit and vegetable-rich diets reduce blood pressure and risk of ischaemic stroke and ischaemic heart disease. While the cardioprotective effects of a fruit and vegetable-rich diet are unequivocal, the exact mechanisms of this effect remain uncertain. Recent evidence has highlighted the possibility that dietary nitrate, an inorganic anion found in large quantities in vegetables (particularly green leafy vegetables), may have a part to play. This beneficial activity lies in the processing in vivo of nitrate to nitrite and thence to the pleiotropic molecule nitric oxide. In this review, recent preclinical and clinical evidence identifying the mechanisms involved in nitrate bioactivity, and the evidence supporting the potential utility of exploitation of this pathway for the prevention and/or treatment of cardiovascular diseases are discussed.",

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author = "V Kapil and Webb, {A J} and A Ahluwalia",

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doi = "10.1136/hrt.2009.180372",

language = "English",

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pages = "1703--1709",

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T1 - Inorganic nitrate and the cardiovascular system

AU - Kapil, V

AU - Webb, A J

AU - Ahluwalia, A

PY - 2010/11

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AB - Fruit and vegetable-rich diets reduce blood pressure and risk of ischaemic stroke and ischaemic heart disease. While the cardioprotective effects of a fruit and vegetable-rich diet are unequivocal, the exact mechanisms of this effect remain uncertain. Recent evidence has highlighted the possibility that dietary nitrate, an inorganic anion found in large quantities in vegetables (particularly green leafy vegetables), may have a part to play. This beneficial activity lies in the processing in vivo of nitrate to nitrite and thence to the pleiotropic molecule nitric oxide. In this review, recent preclinical and clinical evidence identifying the mechanisms involved in nitrate bioactivity, and the evidence supporting the potential utility of exploitation of this pathway for the prevention and/or treatment of cardiovascular diseases are discussed.

KW - Animals

KW - Cardiovascular Diseases

KW - Diet

KW - Fruit

KW - Humans

KW - Hypercholesterolemia

KW - Hypertension

KW - Mice

KW - Myocardial Infarction

KW - Nitrates

KW - Nitric Oxide

KW - Oxygen Consumption

KW - Rats

KW - Vegetables

U2 - 10.1136/hrt.2009.180372

DO - 10.1136/hrt.2009.180372

M3 - Article

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SN - 1355-6037

VL - 96

SP - 1703

EP - 1709

JO - Heart

JF - Heart

IS - 21

ER -

Inorganic nitrate and the cardiovascular system

Abstract

Keywords

UN SDGs

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