Insights into the genetic and molecular basis of primary pulmonary hypertension

TY - JOUR

T1 - Insights into the genetic and molecular basis of primary pulmonary hypertension

AU - Trembath, R C

AU - Harrison, R

PY - 2003/6/1

Y1 - 2003/6/1

N2 - The pathogenesis of primary pulmonary hypertension (PPH) remains poorly understood. Molecular genetic studies have identified that mutations within the gene BMPR2 on the long arm of chromosome 2 underlie familial PPH. This review explores the significance of the PPH gene identification and examines additional genetic determinants, emphasizing the immediate implications for assessment and management of patients and their relatives

AB - The pathogenesis of primary pulmonary hypertension (PPH) remains poorly understood. Molecular genetic studies have identified that mutations within the gene BMPR2 on the long arm of chromosome 2 underlie familial PPH. This review explores the significance of the PPH gene identification and examines additional genetic determinants, emphasizing the immediate implications for assessment and management of patients and their relatives

U2 - 10.1203/01.PDR.0000061565.22500.E7

DO - 10.1203/01.PDR.0000061565.22500.E7

M3 - Literature review

VL - 53

SP - 883

EP - 888

JO - Pediatric Research

JF - Pediatric Research

IS - 6

ER -