Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: an integrated analysis of metabolic and transcriptomic data

TY - JOUR

T1 - Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age

T2 - an integrated analysis of metabolic and transcriptomic data

AU - Stevens, A

AU - Bonshek, C

AU - Whatmore, A

AU - Butcher, I

AU - Hanson, D

AU - De Leonibus, C

AU - Shaikh, G

AU - Brown, M

AU - O'Shea, E

AU - Victor, Suresh

AU - Powel, P

AU - Settle, P

AU - Padmakumar, B

AU - Tan, A

AU - Odeka, E

AU - Cooper, C

AU - Birch, J

AU - Shenoy, A

AU - Westwood, M

AU - Patel, L

AU - Dunn, BW

AU - Clayton, P

PY - 2014

Y1 - 2014

N2 - Small for gestational age (SGA) children exhibiting catch-up (CU) growth have a greater risk of cardiometabolic diseases in later life compared with non-catch-up (NCU) SGA children. The aim of this study was to establish differences in metabolism and gene expression profiles between CU and NCU at age 4-9 years. CU children (n=22) had greater height, weight and body mass index standard deviation scores along with insulin-like growth factor-I (IGF-I) and fasting glucose levels but lower adiponectin values than NCU children (n=11; all P<0.05). Metabolic profiling demonstrated a fourfold decrease of urine myo-inositol in CU compared with NCU (P<0.05). There were 1558 genes differentially expressed in peripheral blood mononuclear cells between the groups (P<0.05). Integrated analysis of data identified myo-inositol related to gene clusters associated with an increase in insulin, growth factor and IGF-I signalling in CU children (P<0.05). Metabolic and transcriptomic profiles in CU SGA children showed changes that may relate to cardiometabolic risk.

AB - Small for gestational age (SGA) children exhibiting catch-up (CU) growth have a greater risk of cardiometabolic diseases in later life compared with non-catch-up (NCU) SGA children. The aim of this study was to establish differences in metabolism and gene expression profiles between CU and NCU at age 4-9 years. CU children (n=22) had greater height, weight and body mass index standard deviation scores along with insulin-like growth factor-I (IGF-I) and fasting glucose levels but lower adiponectin values than NCU children (n=11; all P<0.05). Metabolic profiling demonstrated a fourfold decrease of urine myo-inositol in CU compared with NCU (P<0.05). There were 1558 genes differentially expressed in peripheral blood mononuclear cells between the groups (P<0.05). Integrated analysis of data identified myo-inositol related to gene clusters associated with an increase in insulin, growth factor and IGF-I signalling in CU children (P<0.05). Metabolic and transcriptomic profiles in CU SGA children showed changes that may relate to cardiometabolic risk.

U2 - 10.1038/tpj.2014.4

DO - 10.1038/tpj.2014.4

M3 - Article

SN - 1462-2416

VL - 14

JO - PHARMACOGENOMICS

JF - PHARMACOGENOMICS

IS - 4

ER -