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Insights into Trace Metal Metabolism in Health and Disease from PET: ‘‘PET Metallomics’’

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1355-1359
JournalJournal of Nuclear Medicine
Issue number9
Early online date5 Jul 2018
Accepted/In press11 Jun 2018
E-pub ahead of print5 Jul 2018
PublishedSep 2018


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    Immediate Open Access: Creative Commons Attribution 4.0 International
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King's Authors


Essential trace metals such as copper, zinc, iron, and manganese perform critical functions in cellular and physiologic processes including catalytic, regulatory, and signaling roles. Disturbed metal homeostasis is associated with the pathogenesis of diseases such as dementia, cancer, and inherited metabolic abnormalities. Intracellular pathways involving essential metals have been extensively studied but whole-body fluxes and transport between different compartments remain poorly understood. The growing availability of PET scanners and positron-emitting isotopes of key essential metals, particularly 64Cu, 63Zn, and 52Mn, provide new tools with which to study these processes in vivo. This review highlights opportunities that now present themselves, exemplified by studies of copper metabolism that are in the vanguard of a new research front in molecular imaging: “PET metallomics.”

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