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Instantaneous Conversion of [11C]CO2 to [11C]CO via Fluoride-Activated Disilane Species

Research output: Contribution to journalArticle

Original languageEnglish
JournalChemistry (Weinheim an der Bergstrasse, Germany)
Early online date17 May 2017
DOIs
Publication statusE-pub ahead of print - 17 May 2017

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Abstract

The development of a fast and novel methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) mediated by a fluoride-activated disilane species is described. This methodology allows up to 74% conversion of [11C]CO2 to [11C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl-11C]N-benzylbenzamide was successfully synthesized from produced [11C]CO in up to 74% radiochemical yield (RCY) and >99% radiochemical purity (RCP) in ≤10min from end of [11C]CO2 delivery.

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