Instantaneous Conversion of [11C]CO2 to [11C]CO via Fluoride-Activated Disilane Species

Carlotta Taddei; Salvatore Bongarzone; Antony D. Gee

doi:10.1002/chem.201701661

Instantaneous Conversion of [¹¹C]CO₂ to [¹¹C]CO via Fluoride-Activated Disilane Species

Carlotta Taddei, Salvatore Bongarzone, Antony D. Gee^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The development of a fast and novel methodology to generate carbon-11 carbon monoxide ([¹¹C]CO) from cyclotron-produced carbon-11 carbon dioxide ([¹¹C]CO₂) mediated by a fluoride-activated disilane species is described. This methodology allows up to 74% conversion of [¹¹C]CO₂ to [¹¹C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl-¹¹C]N-benzylbenzamide was successfully synthesized from produced [¹¹C]CO in up to 74% radiochemical yield (RCY) and >99% radiochemical purity (RCP) in ≤10min from end of [¹¹C]CO₂ delivery.

Original language	English
Journal	Chemistry (Weinheim an der Bergstrasse, Germany)
Early online date	17 May 2017
DOIs	https://doi.org/10.1002/chem.201701661
Publication status	E-pub ahead of print - 17 May 2017

Keywords

Carbon-11
Carbonylation
Isotopes
Radiochemistry
Silanes

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Instantaneous Conversion of [11C]CO2_TADDEI_Firstonline17May2017_GOLD VoR (CC-BY)Final published version, 638 KBLicence: CC BY

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title = "Instantaneous Conversion of [11C]CO2 to [11C]CO via Fluoride-Activated Disilane Species",

abstract = "The development of a fast and novel methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) mediated by a fluoride-activated disilane species is described. This methodology allows up to 74% conversion of [11C]CO2 to [11C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl-11C]N-benzylbenzamide was successfully synthesized from produced [11C]CO in up to 74% radiochemical yield (RCY) and >99% radiochemical purity (RCP) in ≤10min from end of [11C]CO2 delivery.",

keywords = "Carbon-11, Carbonylation, Isotopes, Radiochemistry, Silanes",

author = "Carlotta Taddei and Salvatore Bongarzone and Gee, {Antony D.}",

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T1 - Instantaneous Conversion of [11C]CO2 to [11C]CO via Fluoride-Activated Disilane Species

AU - Taddei, Carlotta

AU - Bongarzone, Salvatore

AU - Gee, Antony D.

PY - 2017/5/17

Y1 - 2017/5/17

N2 - The development of a fast and novel methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) mediated by a fluoride-activated disilane species is described. This methodology allows up to 74% conversion of [11C]CO2 to [11C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl-11C]N-benzylbenzamide was successfully synthesized from produced [11C]CO in up to 74% radiochemical yield (RCY) and >99% radiochemical purity (RCP) in ≤10min from end of [11C]CO2 delivery.

AB - The development of a fast and novel methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) mediated by a fluoride-activated disilane species is described. This methodology allows up to 74% conversion of [11C]CO2 to [11C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl-11C]N-benzylbenzamide was successfully synthesized from produced [11C]CO in up to 74% radiochemical yield (RCY) and >99% radiochemical purity (RCP) in ≤10min from end of [11C]CO2 delivery.

KW - Carbon-11

KW - Carbonylation

KW - Isotopes

KW - Radiochemistry

KW - Silanes

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DO - 10.1002/chem.201701661

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JO - Chemistry (Weinheim an der Bergstrasse, Germany)

JF - Chemistry (Weinheim an der Bergstrasse, Germany)

ER -

Instantaneous Conversion of [¹¹C]CO₂ to [¹¹C]CO via Fluoride-Activated Disilane Species

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