Insular pathology in young people with high-functioning autism and first-episode psychosis

M. Parellada; L. Pina-Camacho; C. Moreno; Y. Aleman; M. O. Krebs; M. Desco; J. Merchán-Naranjo; A. Del Rey-Mejías; L. Boada; C. Llorente; D. Moreno; C. Arango; J. Janssen

doi:10.1017/S0033291717000988

Insular pathology in young people with high-functioning autism and first-episode psychosis

M. Parellada^*, L. Pina-Camacho, C. Moreno, Y. Aleman, M. O. Krebs, M. Desco, J. Merchán-Naranjo, A. Del Rey-Mejías, L. Boada, C. Llorente, D. Moreno, C. Arango, J. Janssen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Background Autism Spectrum Disorders (ASD) and psychosis share deficits in social cognition. The insular region has been associated with awareness of self and reality, which may be basic for proper social interactions. Methods Total and regional insular volume and thickness measurements were obtained from a sample of 30 children and adolescents with ASD, 29 with early onset first-episode psychosis (FEP), and 26 healthy controls (HC). Total, regional, and voxel-level volume and thickness measurements were compared between groups (with correction for multiple comparisons), and the relationship between these measurements and symptom severity was explored. Results Compared with HC, a shared volume deficit was observed for the right (but not the left) anterior insula (ASD: p = 0.007, FEP: p = 0.032), and for the bilateral posterior insula: (left, ASD: p = 0.011, FEP: p = 0.033; right, ASD: p = 0.004, FEP: p = 0.028). A voxel-based morphometry (VBM) conjunction analysis showed that ASD and FEP patients shared a gray matter volume and thickness deficit in the left posterior insula. Within patients, right anterior (r = -0.28, p = 0.041) and left posterior (r = -0.29, p = 0.030) insular volumes negatively correlated with the severity of insight deficits, and left posterior insular volume negatively correlated with the severity of 'autistic-like' symptoms (r = -0.30, p = 0.028). Conclusions The shared reduced volume and thickness in the anterior and posterior regions of the insula in ASD and FEP provides the first tentative evidence that these conditions share structural pathology that may be linked to shared symptomatology.

Original language	English
Pages (from-to)	2472-2482
Number of pages	11
Journal	Psychological Medicine
Volume	47
Issue number	14
DOIs	https://doi.org/10.1017/S0033291717000988
Publication status	Published - 1 Oct 2017

Keywords

Autism spectrum disorders
cortical thickness
first-episode psychosis
insula
morphology
volume

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Parellada, M., Pina-Camacho, L., Moreno, C., Aleman, Y., Krebs, M. O., Desco, M., Merchán-Naranjo, J., Del Rey-Mejías, A., Boada, L., Llorente, C., Moreno, D., Arango, C., & Janssen, J. (2017). Insular pathology in young people with high-functioning autism and first-episode psychosis. Psychological Medicine, 47(14), 2472-2482. https://doi.org/10.1017/S0033291717000988

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title = "Insular pathology in young people with high-functioning autism and first-episode psychosis",

abstract = "Background Autism Spectrum Disorders (ASD) and psychosis share deficits in social cognition. The insular region has been associated with awareness of self and reality, which may be basic for proper social interactions. Methods Total and regional insular volume and thickness measurements were obtained from a sample of 30 children and adolescents with ASD, 29 with early onset first-episode psychosis (FEP), and 26 healthy controls (HC). Total, regional, and voxel-level volume and thickness measurements were compared between groups (with correction for multiple comparisons), and the relationship between these measurements and symptom severity was explored. Results Compared with HC, a shared volume deficit was observed for the right (but not the left) anterior insula (ASD: p = 0.007, FEP: p = 0.032), and for the bilateral posterior insula: (left, ASD: p = 0.011, FEP: p = 0.033; right, ASD: p = 0.004, FEP: p = 0.028). A voxel-based morphometry (VBM) conjunction analysis showed that ASD and FEP patients shared a gray matter volume and thickness deficit in the left posterior insula. Within patients, right anterior (r = -0.28, p = 0.041) and left posterior (r = -0.29, p = 0.030) insular volumes negatively correlated with the severity of insight deficits, and left posterior insular volume negatively correlated with the severity of 'autistic-like' symptoms (r = -0.30, p = 0.028). Conclusions The shared reduced volume and thickness in the anterior and posterior regions of the insula in ASD and FEP provides the first tentative evidence that these conditions share structural pathology that may be linked to shared symptomatology.",

keywords = "Autism spectrum disorders, cortical thickness, first-episode psychosis, insula, morphology, volume",

author = "M. Parellada and L. Pina-Camacho and C. Moreno and Y. Aleman and Krebs, {M. O.} and M. Desco and J. Merch{\'a}n-Naranjo and {Del Rey-Mej{\'i}as}, A. and L. Boada and C. Llorente and D. Moreno and C. Arango and J. Janssen",

note = "Publisher Copyright: Copyright {\textcopyright} Cambridge University Press 2017.",

year = "2017",

month = oct,

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doi = "10.1017/S0033291717000988",

language = "English",

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T1 - Insular pathology in young people with high-functioning autism and first-episode psychosis

AU - Parellada, M.

AU - Pina-Camacho, L.

AU - Moreno, C.

AU - Aleman, Y.

AU - Krebs, M. O.

AU - Desco, M.

AU - Merchán-Naranjo, J.

AU - Del Rey-Mejías, A.

AU - Boada, L.

AU - Llorente, C.

AU - Moreno, D.

AU - Arango, C.

AU - Janssen, J.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background Autism Spectrum Disorders (ASD) and psychosis share deficits in social cognition. The insular region has been associated with awareness of self and reality, which may be basic for proper social interactions. Methods Total and regional insular volume and thickness measurements were obtained from a sample of 30 children and adolescents with ASD, 29 with early onset first-episode psychosis (FEP), and 26 healthy controls (HC). Total, regional, and voxel-level volume and thickness measurements were compared between groups (with correction for multiple comparisons), and the relationship between these measurements and symptom severity was explored. Results Compared with HC, a shared volume deficit was observed for the right (but not the left) anterior insula (ASD: p = 0.007, FEP: p = 0.032), and for the bilateral posterior insula: (left, ASD: p = 0.011, FEP: p = 0.033; right, ASD: p = 0.004, FEP: p = 0.028). A voxel-based morphometry (VBM) conjunction analysis showed that ASD and FEP patients shared a gray matter volume and thickness deficit in the left posterior insula. Within patients, right anterior (r = -0.28, p = 0.041) and left posterior (r = -0.29, p = 0.030) insular volumes negatively correlated with the severity of insight deficits, and left posterior insular volume negatively correlated with the severity of 'autistic-like' symptoms (r = -0.30, p = 0.028). Conclusions The shared reduced volume and thickness in the anterior and posterior regions of the insula in ASD and FEP provides the first tentative evidence that these conditions share structural pathology that may be linked to shared symptomatology.

AB - Background Autism Spectrum Disorders (ASD) and psychosis share deficits in social cognition. The insular region has been associated with awareness of self and reality, which may be basic for proper social interactions. Methods Total and regional insular volume and thickness measurements were obtained from a sample of 30 children and adolescents with ASD, 29 with early onset first-episode psychosis (FEP), and 26 healthy controls (HC). Total, regional, and voxel-level volume and thickness measurements were compared between groups (with correction for multiple comparisons), and the relationship between these measurements and symptom severity was explored. Results Compared with HC, a shared volume deficit was observed for the right (but not the left) anterior insula (ASD: p = 0.007, FEP: p = 0.032), and for the bilateral posterior insula: (left, ASD: p = 0.011, FEP: p = 0.033; right, ASD: p = 0.004, FEP: p = 0.028). A voxel-based morphometry (VBM) conjunction analysis showed that ASD and FEP patients shared a gray matter volume and thickness deficit in the left posterior insula. Within patients, right anterior (r = -0.28, p = 0.041) and left posterior (r = -0.29, p = 0.030) insular volumes negatively correlated with the severity of insight deficits, and left posterior insular volume negatively correlated with the severity of 'autistic-like' symptoms (r = -0.30, p = 0.028). Conclusions The shared reduced volume and thickness in the anterior and posterior regions of the insula in ASD and FEP provides the first tentative evidence that these conditions share structural pathology that may be linked to shared symptomatology.

KW - Autism spectrum disorders

KW - cortical thickness

KW - first-episode psychosis

KW - insula

KW - morphology

KW - volume

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DO - 10.1017/S0033291717000988

M3 - Article

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AN - SCOPUS:85018837918

SN - 0033-2917

VL - 47

SP - 2472

EP - 2482

JO - Psychological Medicine

JF - Psychological Medicine

IS - 14

ER -

Insular pathology in young people with high-functioning autism and first-episode psychosis

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