Integrated electrode and high density feedthrough system for chip-scale implantable devices

TY - JOUR

T1 - Integrated electrode and high density feedthrough system for chip-scale implantable devices

AU - Green, Rylie A.

AU - Guenther, Thomas

AU - Jeschke, Christoph

AU - Jaillon, Amandine

AU - Yu, Jin F.

AU - Dueck, Wolfram F.

AU - Lim, William W.

AU - Henderson, William C.

AU - Vanhoestenberghe, Anne

AU - Lovell, Nigel H.

AU - Suaning, Gregg J.

N1 - Funding Information: The authors acknowledge partial funding from University of New South Wales, Silver Star grant scheme , PS24596 and Bionic Vision Australia, a special research initiative (SRI) of the Australian Research Council (ARC) .

PY - 2013/8

Y1 - 2013/8

N2 - High density feedthroughs have been developed which allow for the integration of chip-scale features and electrode arrays with up to 1141 stimulating sites to be located on a single implantable package. This layered technology displays hermetic properties and can be produced from as little as two laminated 200μm thick alumina sheets. It can also be expanded to a greater number of layers to allow flexible routing to integrated electronics. The microelectrodes, which are produced from sintered platinum (Pt) particulate, have high charge injection capacity as a result of a porous surface morphology. Despite their inherent porosity the electrodes are electrically stable following more than 1.8 billion stimulation pulses delivered at clinically relevant levels. The ceramic-Pt constructs are also shown to have acceptable biological properties, causing no cell growth inhibition using standard leachant assays and support neural cell survival and differentiation under both passive conditions and active electrical stimulation.

AB - High density feedthroughs have been developed which allow for the integration of chip-scale features and electrode arrays with up to 1141 stimulating sites to be located on a single implantable package. This layered technology displays hermetic properties and can be produced from as little as two laminated 200μm thick alumina sheets. It can also be expanded to a greater number of layers to allow flexible routing to integrated electronics. The microelectrodes, which are produced from sintered platinum (Pt) particulate, have high charge injection capacity as a result of a porous surface morphology. Despite their inherent porosity the electrodes are electrically stable following more than 1.8 billion stimulation pulses delivered at clinically relevant levels. The ceramic-Pt constructs are also shown to have acceptable biological properties, causing no cell growth inhibition using standard leachant assays and support neural cell survival and differentiation under both passive conditions and active electrical stimulation.

KW - Alumina

KW - Feedthroughs

KW - Hermetic

KW - High-density array

KW - Platinum electrodes

UR - http://www.scopus.com/inward/record.url?scp=84878630317&partnerID=8YFLogxK

U2 - 10.1016/j.biomaterials.2013.04.054

DO - 10.1016/j.biomaterials.2013.04.054

M3 - Article

C2 - 23706781

AN - SCOPUS:84878630317

SN - 0142-9612

VL - 34

SP - 6109

EP - 6118

JO - Biomaterials

JF - Biomaterials

IS - 26

ER -