Integrin Activation: Implications for Axon Regeneration

TY - JOUR

T1 - Integrin Activation

T2 - Implications for Axon Regeneration

AU - Cheah, Menghon

AU - Andrews, Melissa

PY - 2018/3/10

Y1 - 2018/3/10

N2 - Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration.

AB - Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration.

KW - extracellular matrix

KW - gene therapy

KW - integrin activation

KW - kindlin

KW - regeneration

KW - talin

KW - tenascin

UR - https://www.scopus.com/pages/publications/85055462091

U2 - 10.3390/cells7030020

DO - 10.3390/cells7030020

M3 - Article

C2 - 29534450

SN - 2073-4409

VL - 7

SP - 20

JO - Molecules and Cells

JF - Molecules and Cells

IS - 3

ER -