Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia

E Kravariti; T Toulopoulou; F Mapua-Filbey; K Schulze; M Walshe; P Sham; R M Murray; C McDonald

doi:10.1192/bjp.bp.104.008177

Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia

E Kravariti, T Toulopoulou, F Mapua-Filbey, K Schulze, M Walshe, P Sham, R M Murray, C McDonald

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Intellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility to the disorder. We examined the association of a continuous measure of genetic liability to schizophrenia with Verbal-Spatial Contrast IQ (an index of intellectual asymmetry) in 108 first degree relatives without psychosis of probands with schizophrenia, Higher genetic liability was significantly associated with greater intellectual asymmetry in favour of verbal skills. Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia

Original language	English
Pages (from-to)	186 - 187
Number of pages	2
Journal	British Journal of Psychiatry
Volume	188
Issue number	FEB.
DOIs	https://doi.org/10.1192/bjp.bp.104.008177
Publication status	Published - Feb 2006

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AU - Walshe, M

AU - Sham, P

AU - Murray, R M

AU - McDonald, C

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AB - Intellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility to the disorder. We examined the association of a continuous measure of genetic liability to schizophrenia with Verbal-Spatial Contrast IQ (an index of intellectual asymmetry) in 108 first degree relatives without psychosis of probands with schizophrenia, Higher genetic liability was significantly associated with greater intellectual asymmetry in favour of verbal skills. Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia

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Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia

Abstract

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