Interaction between cannabis consumption and childhood abuse in psychotic disorders: Preliminary findings on the role of different patterns of cannabis use

Lucia Sideli; Helen L. Fisher; Robin M. Murray; Hannah Sallis; Manuela Russo; Simona A. Stilo; Alessandra Paparelli; Benjamin D R Wiffen; Jennifer A. O'Connor; Sonia Pintore; Laura Ferraro; Caterina La Cascia; Daniele La Barbera; Craig Morgan; Marta Di Forti

doi:10.1111/eip.12285

Interaction between cannabis consumption and childhood abuse in psychotic disorders: Preliminary findings on the role of different patterns of cannabis use

Lucia Sideli^*, Helen L. Fisher, Robin M. Murray, Hannah Sallis, Manuela Russo, Simona A. Stilo, Alessandra Paparelli, Benjamin D R Wiffen, Jennifer A. O'Connor, Sonia Pintore, Laura Ferraro, Caterina La Cascia, Daniele La Barbera, Craig Morgan, Marta Di Forti

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Aim: Several studies have suggested that lifetime cannabis consumption and childhood abuse synergistically contribute to the risk for psychotic disorders. This study aimed to extend existing findings regarding an additive interaction between childhood abuse and lifetime cannabis use by investigating the moderating role of type and frequency of cannabis use. Methods: Up to 231 individuals presenting for the first time to mental health services with psychotic disorders and 214 unaffected population controls from South London, United Kingdom, were recruited as part of the Genetics and Psychosis study. Information about history of cannabis use was collected using the Cannabis Experiences Questionnaire. Childhood physical and sexual abuse was assessed using the Childhood Experience of Care and Abuse Questionnaire. Results: Neither lifetime cannabis use nor reported exposure to childhood abuse was associated with psychotic disorder when the other environmental variable was taken into account. Although the combination of the two risk factors raised the odds for psychosis by nearly three times (adjusted OR=2.94, 95% CI: 1.44-6.02, P=0.003), no evidence of interaction was found (adjusted OR=1.46, 95% CI: -0.54 to 3.46, P=0.152). Furthermore, the association of high-potency cannabis and daily consumption with psychosis was at least partially independent of the effect of childhood abuse. Conclusions: The heavy use of high-potency cannabis increases the risk of psychosis but, in addition, smoking of traditional resin (hash) and less than daily cannabis use may increase the risk for psychosis when combined with exposure to severe childhood abuse.

Original language	English
Journal	Early Intervention in Psychiatry
DOIs	https://doi.org/10.1111/eip.12285
Publication status	E-pub ahead of print - 12 Nov 2015

Keywords

Cannabis
Childhood trauma
First-episode psychosis
Interaction
Marijuana smoking

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/eip.12285

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Sideli, L., Fisher, H. L., Murray, R. M., Sallis, H., Russo, M., Stilo, S. A., Paparelli, A., Wiffen, B. D. R., O'Connor, J. A., Pintore, S., Ferraro, L., La Cascia, C., La Barbera, D., Morgan, C., & Di Forti, M. (2015). Interaction between cannabis consumption and childhood abuse in psychotic disorders: Preliminary findings on the role of different patterns of cannabis use. Early Intervention in Psychiatry. Advance online publication. https://doi.org/10.1111/eip.12285

@article{fe48208976b4487e9dbdf3cd786ea4d6,

title = "Interaction between cannabis consumption and childhood abuse in psychotic disorders: Preliminary findings on the role of different patterns of cannabis use",

abstract = "Aim: Several studies have suggested that lifetime cannabis consumption and childhood abuse synergistically contribute to the risk for psychotic disorders. This study aimed to extend existing findings regarding an additive interaction between childhood abuse and lifetime cannabis use by investigating the moderating role of type and frequency of cannabis use. Methods: Up to 231 individuals presenting for the first time to mental health services with psychotic disorders and 214 unaffected population controls from South London, United Kingdom, were recruited as part of the Genetics and Psychosis study. Information about history of cannabis use was collected using the Cannabis Experiences Questionnaire. Childhood physical and sexual abuse was assessed using the Childhood Experience of Care and Abuse Questionnaire. Results: Neither lifetime cannabis use nor reported exposure to childhood abuse was associated with psychotic disorder when the other environmental variable was taken into account. Although the combination of the two risk factors raised the odds for psychosis by nearly three times (adjusted OR=2.94, 95% CI: 1.44-6.02, P=0.003), no evidence of interaction was found (adjusted OR=1.46, 95% CI: -0.54 to 3.46, P=0.152). Furthermore, the association of high-potency cannabis and daily consumption with psychosis was at least partially independent of the effect of childhood abuse. Conclusions: The heavy use of high-potency cannabis increases the risk of psychosis but, in addition, smoking of traditional resin (hash) and less than daily cannabis use may increase the risk for psychosis when combined with exposure to severe childhood abuse.",

keywords = "Cannabis, Childhood trauma, First-episode psychosis, Interaction, Marijuana smoking",

author = "Lucia Sideli and Fisher, {Helen L.} and Murray, {Robin M.} and Hannah Sallis and Manuela Russo and Stilo, {Simona A.} and Alessandra Paparelli and Wiffen, {Benjamin D R} and O'Connor, {Jennifer A.} and Sonia Pintore and Laura Ferraro and {La Cascia}, Caterina and {La Barbera}, Daniele and Craig Morgan and {Di Forti}, Marta",

year = "2015",

month = nov,

day = "12",

doi = "10.1111/eip.12285",

language = "English",

journal = "Early Intervention in Psychiatry",

issn = "1751-7885",

publisher = "Wiley",

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Sideli, L, Fisher, HL, Murray, RM, Sallis, H, Russo, M , Stilo, SA , Paparelli, A , Wiffen, BDR , O'Connor, JA, Pintore, S, Ferraro, L, La Cascia, C, La Barbera, D, Morgan, C & Di Forti, M 2015, 'Interaction between cannabis consumption and childhood abuse in psychotic disorders: Preliminary findings on the role of different patterns of cannabis use', Early Intervention in Psychiatry. https://doi.org/10.1111/eip.12285

TY - JOUR

T1 - Interaction between cannabis consumption and childhood abuse in psychotic disorders

T2 - Preliminary findings on the role of different patterns of cannabis use

AU - Sideli, Lucia

AU - Fisher, Helen L.

AU - Murray, Robin M.

AU - Sallis, Hannah

AU - Russo, Manuela

AU - Stilo, Simona A.

AU - Paparelli, Alessandra

AU - Wiffen, Benjamin D R

AU - O'Connor, Jennifer A.

AU - Pintore, Sonia

AU - Ferraro, Laura

AU - La Cascia, Caterina

AU - La Barbera, Daniele

AU - Morgan, Craig

AU - Di Forti, Marta

PY - 2015/11/12

Y1 - 2015/11/12

N2 - Aim: Several studies have suggested that lifetime cannabis consumption and childhood abuse synergistically contribute to the risk for psychotic disorders. This study aimed to extend existing findings regarding an additive interaction between childhood abuse and lifetime cannabis use by investigating the moderating role of type and frequency of cannabis use. Methods: Up to 231 individuals presenting for the first time to mental health services with psychotic disorders and 214 unaffected population controls from South London, United Kingdom, were recruited as part of the Genetics and Psychosis study. Information about history of cannabis use was collected using the Cannabis Experiences Questionnaire. Childhood physical and sexual abuse was assessed using the Childhood Experience of Care and Abuse Questionnaire. Results: Neither lifetime cannabis use nor reported exposure to childhood abuse was associated with psychotic disorder when the other environmental variable was taken into account. Although the combination of the two risk factors raised the odds for psychosis by nearly three times (adjusted OR=2.94, 95% CI: 1.44-6.02, P=0.003), no evidence of interaction was found (adjusted OR=1.46, 95% CI: -0.54 to 3.46, P=0.152). Furthermore, the association of high-potency cannabis and daily consumption with psychosis was at least partially independent of the effect of childhood abuse. Conclusions: The heavy use of high-potency cannabis increases the risk of psychosis but, in addition, smoking of traditional resin (hash) and less than daily cannabis use may increase the risk for psychosis when combined with exposure to severe childhood abuse.

AB - Aim: Several studies have suggested that lifetime cannabis consumption and childhood abuse synergistically contribute to the risk for psychotic disorders. This study aimed to extend existing findings regarding an additive interaction between childhood abuse and lifetime cannabis use by investigating the moderating role of type and frequency of cannabis use. Methods: Up to 231 individuals presenting for the first time to mental health services with psychotic disorders and 214 unaffected population controls from South London, United Kingdom, were recruited as part of the Genetics and Psychosis study. Information about history of cannabis use was collected using the Cannabis Experiences Questionnaire. Childhood physical and sexual abuse was assessed using the Childhood Experience of Care and Abuse Questionnaire. Results: Neither lifetime cannabis use nor reported exposure to childhood abuse was associated with psychotic disorder when the other environmental variable was taken into account. Although the combination of the two risk factors raised the odds for psychosis by nearly three times (adjusted OR=2.94, 95% CI: 1.44-6.02, P=0.003), no evidence of interaction was found (adjusted OR=1.46, 95% CI: -0.54 to 3.46, P=0.152). Furthermore, the association of high-potency cannabis and daily consumption with psychosis was at least partially independent of the effect of childhood abuse. Conclusions: The heavy use of high-potency cannabis increases the risk of psychosis but, in addition, smoking of traditional resin (hash) and less than daily cannabis use may increase the risk for psychosis when combined with exposure to severe childhood abuse.

KW - Cannabis

KW - Childhood trauma

KW - First-episode psychosis

KW - Interaction

KW - Marijuana smoking

UR - http://www.scopus.com/inward/record.url?scp=84947998893&partnerID=8YFLogxK

U2 - 10.1111/eip.12285

DO - 10.1111/eip.12285

M3 - Article

AN - SCOPUS:84947998893

SN - 1751-7885

JO - Early Intervention in Psychiatry

JF - Early Intervention in Psychiatry

ER -

Interaction between cannabis consumption and childhood abuse in psychotic disorders: Preliminary findings on the role of different patterns of cannabis use

Abstract

Keywords

UN SDGs

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