Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort

for the ENIGMA-MDD Consortium

doi:10.1017/S003329171900093X

Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort

for the ENIGMA-MDD Consortium

Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke-University Hospital Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
SAMRC Unit on Risk and Resilience in Mental Disorders
Institute for Musculoskeletal Health, The University of Sydney and Sydney Local Health District , Sydney, Australia
Trinity College Dublin
Charité University of Medicine Berlin
Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Department of Epileptology, University Hospital Bonn, Bonn, Germany
Department of Psychosomatics and Psychotherapy, University Hospital Münster, Münster, Germany.
Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre, Freiburg, Freiburg, Germany.
Department of Psychiatry, Psychotherapy and Psychosomatic Medicine with Early Intervention and Recognition Centre (FRITZ), Vivantes Klinikum Am Urban, Charité-Universitätsmedizin, Berlin, Germany; Vivantes Klinikum im Friedrichshain, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Charité-Universitätsmedizin, Berlin, Germany; ORYGEN, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia; Department of Psychiatry and Psychotherapy, University of Cologne,
Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg Philipps‐Universität Marburg Marburg Germany
Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway.
Curtin University
College of Applied Health and Communities
Research Department of Epidemiology and Public Health, University College London, UK; School of Psychology, University of East London, London, UK.
Health Psychology Section, Psychology Department, Institute of Psychology, Psychiatry and Neuroscience, King's College London, United Kingdom.
1Department of Hepatology, Imperial College London, London, UK. 2Institute of Liver Studies at King's College School of Medicine at King's College Hospital, London, UK. 3Institute of Human Health and Performance, University College London, London, UK. 4Department of Asthma Allergy and Lung Biology, King's College London, London, UK. 5Division of Critical Care Medicine, University of Alberta, Edmonton, Canada.
Centre for Pain Research, University of Bath, Department of Experimental Psychology, University of Oxford, Department of Anaesthesiology & Pain Medicine, University of Washington, Clinical Health Psychology, University College London, and University College London Hospitals, and Psychology Department, Kings College London.
School of Education, Faculty of Arts and Social Sciences, UNSW Australia, Sydney NSW 2052, Australia.
Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei City
Univ London, Birkbeck University London, University College London, University of London Royal Veterinary College, University of London, St Georges University London, Imperial College London, Kings College London, Royal Holloway University London, Queen Mary University London, Div Populat Hlth Sci & Educ
Neuroimaging Department
California State University
Leibniz Institute for Neurobiology
Keck School of Medicine of University of California
VA San Diego Healthcare

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.

METHODS: Within the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.

RESULTS: CM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.

CONCLUSIONS: Severity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind.

Original language	English
Pages (from-to)	1020-1031
Number of pages	12
Journal	Psychological Medicine
Volume	50
Issue number	6
DOIs	https://doi.org/10.1017/S003329171900093X
Publication status	Published - Apr 2020

Keywords

Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Brain Cortical Thickness
Case-Control Studies
Cerebral Cortex/pathology
Child
Child Abuse
Cohort Studies
Depressive Disorder, Major/pathology
Female
Gyrus Cinguli/pathology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Parietal Lobe/pathology
Prefrontal Cortex/pathology
Temporal Lobe/pathology
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1017/S003329171900093X

Cite this

@article{f4e9cd2de72744dc962a14a881c6f301,

title = "Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort",

abstract = "BACKGROUND: Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.METHODS: Within the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.RESULTS: CM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.CONCLUSIONS: Severity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind.",

keywords = "Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Brain Cortical Thickness, Case-Control Studies, Cerebral Cortex/pathology, Child, Child Abuse, Cohort Studies, Depressive Disorder, Major/pathology, Female, Gyrus Cinguli/pathology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parietal Lobe/pathology, Prefrontal Cortex/pathology, Temporal Lobe/pathology, Young Adult",

author = "{for the ENIGMA-MDD Consortium} and Leonardo Tozzi and Lisa Garczarek and Deborah Janowitz and Stein, {Dan J} and Katharina Wittfeld and Henrik Dobrowolny and Jim Lagopoulos and Hatton, {Sean N} and Hickie, {Ian B} and Angela Carballedo and Brooks, {Samantha J} and Daniella Vuletic and Anne Uhlmann and Veer, {Ilya M} and Henrik Walter and Robin B{\"u}low and Henry V{\"o}lzke and Johanna Klinger-K{\"o}nig and Knut Schnell and Dieter Schoepf and Dominik Grotegerd and Nils Opel and Udo Dannlowski and Harald Kugel and Elisabeth Schramm and Carsten Konrad and Tilo Kircher and Dilara J{\"u}ksel and Igor Nenadi{\'c} and Axel Krug and Tim Hahn and Olaf Steinstr{\"a}ter and Ronny Redlich and Dario Zaremba and Bartosz Zurowski and Fu, {Cynthia H Y} and Danai Dima and James Cole and Grabe, {Hans J} and Connolly, {Colm G} and Yang, {Tony T} and Ho, {Tiffany C} and LeWinn, {Kaja Z} and Meng Li and Groenewold, {Nynke A} and Salminen, {Lauren E} and Martin Walter and Simmons, {Alan N} and {van Erp}, {Theo G M} and Neda Jahanshad",

year = "2020",

month = apr,

doi = "10.1017/S003329171900093X",

language = "English",

volume = "50",

pages = "1020--1031",

journal = "Psychological Medicine",

issn = "0033-2917",

publisher = "Cambridge University Press",

number = "6",

}

TY - JOUR

T1 - Interactive impact of childhood maltreatment, depression, and age on cortical brain structure

T2 - mega-analytic findings from a large multi-site cohort

AU - for the ENIGMA-MDD Consortium

AU - Tozzi, Leonardo

AU - Garczarek, Lisa

AU - Janowitz, Deborah

AU - Stein, Dan J

AU - Wittfeld, Katharina

AU - Dobrowolny, Henrik

AU - Lagopoulos, Jim

AU - Hatton, Sean N

AU - Hickie, Ian B

AU - Carballedo, Angela

AU - Brooks, Samantha J

AU - Vuletic, Daniella

AU - Uhlmann, Anne

AU - Veer, Ilya M

AU - Walter, Henrik

AU - Bülow, Robin

AU - Völzke, Henry

AU - Klinger-König, Johanna

AU - Schnell, Knut

AU - Schoepf, Dieter

AU - Grotegerd, Dominik

AU - Opel, Nils

AU - Dannlowski, Udo

AU - Kugel, Harald

AU - Schramm, Elisabeth

AU - Konrad, Carsten

AU - Kircher, Tilo

AU - Jüksel, Dilara

AU - Nenadić, Igor

AU - Krug, Axel

AU - Hahn, Tim

AU - Steinsträter, Olaf

AU - Redlich, Ronny

AU - Zaremba, Dario

AU - Zurowski, Bartosz

AU - Fu, Cynthia H Y

AU - Dima, Danai

AU - Cole, James

AU - Grabe, Hans J

AU - Connolly, Colm G

AU - Yang, Tony T

AU - Ho, Tiffany C

AU - LeWinn, Kaja Z

AU - Li, Meng

AU - Groenewold, Nynke A

AU - Salminen, Lauren E

AU - Walter, Martin

AU - Simmons, Alan N

AU - van Erp, Theo G M

AU - Jahanshad, Neda

PY - 2020/4

Y1 - 2020/4

N2 - BACKGROUND: Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.METHODS: Within the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.RESULTS: CM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.CONCLUSIONS: Severity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind.

AB - BACKGROUND: Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.METHODS: Within the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.RESULTS: CM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.CONCLUSIONS: Severity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Brain Cortical Thickness

KW - Case-Control Studies

KW - Cerebral Cortex/pathology

KW - Child

KW - Child Abuse

KW - Cohort Studies

KW - Depressive Disorder, Major/pathology

KW - Female

KW - Gyrus Cinguli/pathology

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Parietal Lobe/pathology

KW - Prefrontal Cortex/pathology

KW - Temporal Lobe/pathology

KW - Young Adult

U2 - 10.1017/S003329171900093X

DO - 10.1017/S003329171900093X

M3 - Article

C2 - 31084657

SN - 0033-2917

VL - 50

SP - 1020

EP - 1031

JO - Psychological Medicine

JF - Psychological Medicine

IS - 6

ER -

Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort

Abstract

Keywords

UN SDGs

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