Intercellular IgA dermatosis (IgA pemphigus) - two cases illustrating the clinical heterogeneity of this disorder

TY - JOUR

T1 - Intercellular IgA dermatosis (IgA pemphigus) - two cases illustrating the clinical heterogeneity of this disorder

AU - Harman, K E

AU - Holmes, G

AU - Bhogal, B S

AU - McFadden, J

AU - Black, M M

PY - 1999

Y1 - 1999

N2 - IgA pemphigus is rare but may be underdiagnosed. We describe two cases, a 50-year-old female with a pustular eruption resembling subcorneal pustular dermatosis and a 55-year-old male with a pruritic vesiculopustular eruption simulating dermatitis herpetiformis. They illustrate the clinical heterogeneity of IgA pemphigus which is likely to reflect differences in autoantigens, analogous to pemphigus vulgaris and pemphigus foliaceus. There is now evidence that IgA pemphigus encompasses at least two subgroups: a subcorneal pustular dermatosis (SPD)-type, (see case 1) characterized by subcorneal pustules and autoantibodies to desmocollin 1; and intra-epidermal neutrophilic dermatosis (IEN)-type cases (see case 2) which show intra-epidermal pustules and in whom the autoantigen may be desmoglein 3, the pemphigus vulgaris antigen.

AB - IgA pemphigus is rare but may be underdiagnosed. We describe two cases, a 50-year-old female with a pustular eruption resembling subcorneal pustular dermatosis and a 55-year-old male with a pruritic vesiculopustular eruption simulating dermatitis herpetiformis. They illustrate the clinical heterogeneity of IgA pemphigus which is likely to reflect differences in autoantigens, analogous to pemphigus vulgaris and pemphigus foliaceus. There is now evidence that IgA pemphigus encompasses at least two subgroups: a subcorneal pustular dermatosis (SPD)-type, (see case 1) characterized by subcorneal pustules and autoantibodies to desmocollin 1; and intra-epidermal neutrophilic dermatosis (IEN)-type cases (see case 2) which show intra-epidermal pustules and in whom the autoantigen may be desmoglein 3, the pemphigus vulgaris antigen.

UR - http://www.scopus.com/inward/record.url?scp=0033428959&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2230.1999.00534.x

DO - 10.1046/j.1365-2230.1999.00534.x

M3 - Article

SN - 1365-2230

VL - 24

SP - 464

EP - 466

JO - Clinical and Experimental Dermatology

JF - Clinical and Experimental Dermatology

IS - 6

ER -