King's College London

Research portal

Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus

Research output: Contribution to journalArticlepeer-review

Standard

Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus. / Odhams, Christopher A; Roberts, Amy L; Vester, Susan K et al.

In: Nature Communications, Vol. 10, 2164, 31.05.2019, p. 1-15.

Research output: Contribution to journalArticlepeer-review

Harvard

Odhams, CA, Roberts, AL, Vester, SK, S T Duarte, C, Beales, CT, Clarke, AJ, Lindinger, S, Daffern, SJ, Zito, A, Chen, L, Jones, LL, Boteva, L, Morris, DL, Small, KS, Fernando, MMA, Cunninghame Graham, DS & Vyse, TJ 2019, 'Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus', Nature Communications, vol. 10, 2164, pp. 1-15. https://doi.org/10.1038/s41467-019-10106-2

APA

Odhams, C. A., Roberts, A. L., Vester, S. K., S T Duarte, C., Beales, C. T., Clarke, A. J., Lindinger, S., Daffern, S. J., Zito, A., Chen, L., Jones, L. L., Boteva, L., Morris, D. L., Small, K. S., Fernando, M. M. A., Cunninghame Graham, D. S., & Vyse, T. J. (2019). Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus. Nature Communications, 10, 1-15. [2164]. https://doi.org/10.1038/s41467-019-10106-2

Vancouver

Odhams CA, Roberts AL, Vester SK, S T Duarte C, Beales CT, Clarke AJ et al. Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus. Nature Communications. 2019 May 31;10:1-15. 2164. https://doi.org/10.1038/s41467-019-10106-2

Author

Odhams, Christopher A ; Roberts, Amy L ; Vester, Susan K et al. / Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus. In: Nature Communications. 2019 ; Vol. 10. pp. 1-15.

Bibtex Download

@article{8df50bef42fb44cf9f5ce6efb68ea990,
title = "Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus",
abstract = "Systemic lupus erythematosus (SLE) is an autoimmune disease, characterised by increased expression of type I interferon (IFN) regulated genes and a striking sex imbalance towards females. Through combined genetic, in silico, in vitro, and ex vivo approaches, we define CXorf21, a gene of hitherto unknown function, which escapes X-chromosome inactivation, as a candidate underlying the Xp21.2 SLE association. We demonstrate that CXorf21 is an IFNresponse gene and that the sexual dimorphism in expression is magnified by immunological challenge. Fine-mapping reveals a single haplotype as a potential causal cis-eQTL for CXorf21. We propose that expression is amplified through modification of promoter and 3-UTR chromatin interactions. Finally, we show that the CXORF21 protein colocalises with TLR7, a pathway implicated in SLE pathogenesis. Our study reveals modulation in gene expression affected by the combination of two hallmarks of SLE: CXorf21 expression increases in a both an IFN-inducible and sex-specific manner.",
keywords = "X chromosome, LUPUS-ERYTHEMATOSUS, Autoimmune diseases, gene",
author = "Odhams, {Christopher A} and Roberts, {Amy L} and Vester, {Susan K} and {S T Duarte}, Carolina and Beales, {Charlie T} and Clarke, {Alexander J} and Sonja Lindinger and Daffern, {Samuel J} and Antonino Zito and Lingyan Chen and Jones, {Leonardo L} and Lora Boteva and Morris, {David L} and Small, {Kerrin S} and Fernando, {Michelle M A} and {Cunninghame Graham}, {Deborah S} and Vyse, {Timothy J}",
year = "2019",
month = may,
day = "31",
doi = "10.1038/s41467-019-10106-2",
language = "English",
volume = "10",
pages = "1--15",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus

AU - Odhams, Christopher A

AU - Roberts, Amy L

AU - Vester, Susan K

AU - S T Duarte, Carolina

AU - Beales, Charlie T

AU - Clarke, Alexander J

AU - Lindinger, Sonja

AU - Daffern, Samuel J

AU - Zito, Antonino

AU - Chen, Lingyan

AU - Jones, Leonardo L

AU - Boteva, Lora

AU - Morris, David L

AU - Small, Kerrin S

AU - Fernando, Michelle M A

AU - Cunninghame Graham, Deborah S

AU - Vyse, Timothy J

PY - 2019/5/31

Y1 - 2019/5/31

N2 - Systemic lupus erythematosus (SLE) is an autoimmune disease, characterised by increased expression of type I interferon (IFN) regulated genes and a striking sex imbalance towards females. Through combined genetic, in silico, in vitro, and ex vivo approaches, we define CXorf21, a gene of hitherto unknown function, which escapes X-chromosome inactivation, as a candidate underlying the Xp21.2 SLE association. We demonstrate that CXorf21 is an IFNresponse gene and that the sexual dimorphism in expression is magnified by immunological challenge. Fine-mapping reveals a single haplotype as a potential causal cis-eQTL for CXorf21. We propose that expression is amplified through modification of promoter and 3-UTR chromatin interactions. Finally, we show that the CXORF21 protein colocalises with TLR7, a pathway implicated in SLE pathogenesis. Our study reveals modulation in gene expression affected by the combination of two hallmarks of SLE: CXorf21 expression increases in a both an IFN-inducible and sex-specific manner.

AB - Systemic lupus erythematosus (SLE) is an autoimmune disease, characterised by increased expression of type I interferon (IFN) regulated genes and a striking sex imbalance towards females. Through combined genetic, in silico, in vitro, and ex vivo approaches, we define CXorf21, a gene of hitherto unknown function, which escapes X-chromosome inactivation, as a candidate underlying the Xp21.2 SLE association. We demonstrate that CXorf21 is an IFNresponse gene and that the sexual dimorphism in expression is magnified by immunological challenge. Fine-mapping reveals a single haplotype as a potential causal cis-eQTL for CXorf21. We propose that expression is amplified through modification of promoter and 3-UTR chromatin interactions. Finally, we show that the CXORF21 protein colocalises with TLR7, a pathway implicated in SLE pathogenesis. Our study reveals modulation in gene expression affected by the combination of two hallmarks of SLE: CXorf21 expression increases in a both an IFN-inducible and sex-specific manner.

KW - X chromosome

KW - LUPUS-ERYTHEMATOSUS

KW - Autoimmune diseases

KW - gene

U2 - 10.1038/s41467-019-10106-2

DO - 10.1038/s41467-019-10106-2

M3 - Article

VL - 10

SP - 1

EP - 15

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2164

ER -

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454