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Interferon-alpha-induced depression: Comparisons between early- and late-onset subgroups and with patients with major depressive disorder

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Interferon-alpha-induced depression : Comparisons between early- and late-onset subgroups and with patients with major depressive disorder. / Su, Kuan-pin; Lai, Hsueh-chou; Peng, Cheng-yuan; Su, Wen-pang; Chang, Jane Pei-chen; Pariante, Carmine M.

In: Brain, Behavior, and Immunity, Vol. 80, 08.2019, p. 512-518.

Research output: Contribution to journalArticle

Harvard

Su, K, Lai, H, Peng, C, Su, W, Chang, JP & Pariante, CM 2019, 'Interferon-alpha-induced depression: Comparisons between early- and late-onset subgroups and with patients with major depressive disorder', Brain, Behavior, and Immunity, vol. 80, pp. 512-518. https://doi.org/10.1016/j.bbi.2019.04.032

APA

Su, K., Lai, H., Peng, C., Su, W., Chang, J. P., & Pariante, C. M. (2019). Interferon-alpha-induced depression: Comparisons between early- and late-onset subgroups and with patients with major depressive disorder. Brain, Behavior, and Immunity, 80, 512-518. https://doi.org/10.1016/j.bbi.2019.04.032

Vancouver

Su K, Lai H, Peng C, Su W, Chang JP, Pariante CM. Interferon-alpha-induced depression: Comparisons between early- and late-onset subgroups and with patients with major depressive disorder. Brain, Behavior, and Immunity. 2019 Aug;80:512-518. https://doi.org/10.1016/j.bbi.2019.04.032

Author

Su, Kuan-pin ; Lai, Hsueh-chou ; Peng, Cheng-yuan ; Su, Wen-pang ; Chang, Jane Pei-chen ; Pariante, Carmine M. / Interferon-alpha-induced depression : Comparisons between early- and late-onset subgroups and with patients with major depressive disorder. In: Brain, Behavior, and Immunity. 2019 ; Vol. 80. pp. 512-518.

Bibtex Download

@article{b61348aa525f4b4a82d11f7bc79e9bff,
title = "Interferon-alpha-induced depression: Comparisons between early- and late-onset subgroups and with patients with major depressive disorder",
abstract = "Interferon (IFN)-alpha, until recently the standard treatment of hepatitis C virus (HCV) infection, is associated with a significant risk of major depressive episode (MDE, or IFN-alpha-induced depression). However, it is little studied the comparisons of clinical manifestations between IFN-alpha-induced depression and major depressive disorder (MDD). In addition, IFN-alpha induces different neuroinflammation and neuroendocrine status throughput the HCV treatment course; however, the clinical presentations have never been compared between early-onset and later-onset IFN-alpha-induced depression. We assessed 200 HCV patients starting IFN-alpha therapy bi-weekly for 24 weeks, with the structured interview for confirmation of diagnosis of IFN-alpha-induced depression and with clinical rating scales for depressive symptoms and neuropsychiatric symptoms. Subjects developed IFN-alpha-induced depression (n = 59, 30%) during the first 6 weeks of IFN-alpha therapy were defined as the early-onset group (n = 32), while those developed depression after the 6th week were defined as the late-onset group (n = 27). A matched group of MDD patients (n = 60) was used to compare specific clusters of depressive symptoms with early- and late-onset IFN-alpha-induced depression. Compared to the matched group of MDD patients, IFN-alpha-induced depression was significantly associated with more somatic symptoms and fewer symptoms of mood, anxiety and negative cognition. More somatic symptoms were also found in those who became clinically depressed at early stage of IFN-alpha therapy. We suggest that the specific somatic features of interferon-alpha-induced depression, and especially of early-onset depression, characterise individuals who are more sensitive to cytokines-induced changes in mood.",
keywords = "Inflammation, Interferon-alpha (IFN-α), Major depressive disorder (MDD), Somatic, Subtyping",
author = "Kuan-pin Su and Hsueh-chou Lai and Cheng-yuan Peng and Wen-pang Su and Chang, {Jane Pei-chen} and Pariante, {Carmine M.}",
year = "2019",
month = aug,
doi = "10.1016/j.bbi.2019.04.032",
language = "English",
volume = "80",
pages = "512--518",
journal = "Brain Behavior and Immunity",
issn = "0889-1591",
publisher = "ACADEMIC PRESS INC",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Interferon-alpha-induced depression

T2 - Comparisons between early- and late-onset subgroups and with patients with major depressive disorder

AU - Su, Kuan-pin

AU - Lai, Hsueh-chou

AU - Peng, Cheng-yuan

AU - Su, Wen-pang

AU - Chang, Jane Pei-chen

AU - Pariante, Carmine M.

PY - 2019/8

Y1 - 2019/8

N2 - Interferon (IFN)-alpha, until recently the standard treatment of hepatitis C virus (HCV) infection, is associated with a significant risk of major depressive episode (MDE, or IFN-alpha-induced depression). However, it is little studied the comparisons of clinical manifestations between IFN-alpha-induced depression and major depressive disorder (MDD). In addition, IFN-alpha induces different neuroinflammation and neuroendocrine status throughput the HCV treatment course; however, the clinical presentations have never been compared between early-onset and later-onset IFN-alpha-induced depression. We assessed 200 HCV patients starting IFN-alpha therapy bi-weekly for 24 weeks, with the structured interview for confirmation of diagnosis of IFN-alpha-induced depression and with clinical rating scales for depressive symptoms and neuropsychiatric symptoms. Subjects developed IFN-alpha-induced depression (n = 59, 30%) during the first 6 weeks of IFN-alpha therapy were defined as the early-onset group (n = 32), while those developed depression after the 6th week were defined as the late-onset group (n = 27). A matched group of MDD patients (n = 60) was used to compare specific clusters of depressive symptoms with early- and late-onset IFN-alpha-induced depression. Compared to the matched group of MDD patients, IFN-alpha-induced depression was significantly associated with more somatic symptoms and fewer symptoms of mood, anxiety and negative cognition. More somatic symptoms were also found in those who became clinically depressed at early stage of IFN-alpha therapy. We suggest that the specific somatic features of interferon-alpha-induced depression, and especially of early-onset depression, characterise individuals who are more sensitive to cytokines-induced changes in mood.

AB - Interferon (IFN)-alpha, until recently the standard treatment of hepatitis C virus (HCV) infection, is associated with a significant risk of major depressive episode (MDE, or IFN-alpha-induced depression). However, it is little studied the comparisons of clinical manifestations between IFN-alpha-induced depression and major depressive disorder (MDD). In addition, IFN-alpha induces different neuroinflammation and neuroendocrine status throughput the HCV treatment course; however, the clinical presentations have never been compared between early-onset and later-onset IFN-alpha-induced depression. We assessed 200 HCV patients starting IFN-alpha therapy bi-weekly for 24 weeks, with the structured interview for confirmation of diagnosis of IFN-alpha-induced depression and with clinical rating scales for depressive symptoms and neuropsychiatric symptoms. Subjects developed IFN-alpha-induced depression (n = 59, 30%) during the first 6 weeks of IFN-alpha therapy were defined as the early-onset group (n = 32), while those developed depression after the 6th week were defined as the late-onset group (n = 27). A matched group of MDD patients (n = 60) was used to compare specific clusters of depressive symptoms with early- and late-onset IFN-alpha-induced depression. Compared to the matched group of MDD patients, IFN-alpha-induced depression was significantly associated with more somatic symptoms and fewer symptoms of mood, anxiety and negative cognition. More somatic symptoms were also found in those who became clinically depressed at early stage of IFN-alpha therapy. We suggest that the specific somatic features of interferon-alpha-induced depression, and especially of early-onset depression, characterise individuals who are more sensitive to cytokines-induced changes in mood.

KW - Inflammation

KW - Interferon-alpha (IFN-α)

KW - Major depressive disorder (MDD)

KW - Somatic

KW - Subtyping

U2 - 10.1016/j.bbi.2019.04.032

DO - 10.1016/j.bbi.2019.04.032

M3 - Article

VL - 80

SP - 512

EP - 518

JO - Brain Behavior and Immunity

JF - Brain Behavior and Immunity

SN - 0889-1591

ER -

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