Intervention by retinoic acid in oxidative stress-induced apoptosis

M Kitamura; Y Ishikawa; V Moreno-Manzano; Q H Xu; T Konta; J Lucio-Cazana; A Furusu; K Nakayama

doi:10.1093/ndt/17.suppl_9.84

Intervention by retinoic acid in oxidative stress-induced apoptosis

M Kitamura, Y Ishikawa, V Moreno-Manzano, Q H Xu, T Konta, J Lucio-Cazana, A Furusu, K Nakayama

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Abstract

Retinoic acid (RA) has been considered a proapoptotic agent, and little is known about its antiapoptotic potential. In this article, we describe that RA strongly inhibits hydrogen peroxide (H2O2)-induced apoptosis of mesangial cells by intervention in activator protein 1 (AP-1). Our data showed that: (i) H2O2 induces apoptosis of mesangial cells via the AP-1 pathway; (iii) activation of AP-1 by H2O2 is mediated by the c-Jun N-terminal kinase (JNK)-c-Jun/AP-1 pathway and the extracellular signal-regulated kinase-c-Fos/AP-1 pathway; (iii) RA inhibits H2O2-induced apoptosis via suppression of c-fos/c-jun expression and JNK activation; and (iv) the anti-apoptotic effect of RA is, at least in part, mediated by induction of mitogen-activated protein kinase phosphatase 1

Original language	English
Pages (from-to)	84 - 87
Number of pages	4
Journal	Nephrology, Dialysis, Transplantation
Volume	17
Issue number	SUPPL. 9
DOIs	https://doi.org/10.1093/ndt/17.suppl_9.84
Publication status	Published - 2002

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10.1093/ndt/17.suppl_9.84

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title = "Intervention by retinoic acid in oxidative stress-induced apoptosis",

abstract = "Retinoic acid (RA) has been considered a proapoptotic agent, and little is known about its antiapoptotic potential. In this article, we describe that RA strongly inhibits hydrogen peroxide (H2O2)-induced apoptosis of mesangial cells by intervention in activator protein 1 (AP-1). Our data showed that: (i) H2O2 induces apoptosis of mesangial cells via the AP-1 pathway; (iii) activation of AP-1 by H2O2 is mediated by the c-Jun N-terminal kinase (JNK)-c-Jun/AP-1 pathway and the extracellular signal-regulated kinase-c-Fos/AP-1 pathway; (iii) RA inhibits H2O2-induced apoptosis via suppression of c-fos/c-jun expression and JNK activation; and (iv) the anti-apoptotic effect of RA is, at least in part, mediated by induction of mitogen-activated protein kinase phosphatase 1",

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doi = "10.1093/ndt/17.suppl_9.84",

language = "English",

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TY - JOUR

T1 - Intervention by retinoic acid in oxidative stress-induced apoptosis

AU - Kitamura, M

AU - Ishikawa, Y

AU - Moreno-Manzano, V

AU - Xu, Q H

AU - Konta, T

AU - Lucio-Cazana, J

AU - Furusu, A

AU - Nakayama, K

PY - 2002

Y1 - 2002

N2 - Retinoic acid (RA) has been considered a proapoptotic agent, and little is known about its antiapoptotic potential. In this article, we describe that RA strongly inhibits hydrogen peroxide (H2O2)-induced apoptosis of mesangial cells by intervention in activator protein 1 (AP-1). Our data showed that: (i) H2O2 induces apoptosis of mesangial cells via the AP-1 pathway; (iii) activation of AP-1 by H2O2 is mediated by the c-Jun N-terminal kinase (JNK)-c-Jun/AP-1 pathway and the extracellular signal-regulated kinase-c-Fos/AP-1 pathway; (iii) RA inhibits H2O2-induced apoptosis via suppression of c-fos/c-jun expression and JNK activation; and (iv) the anti-apoptotic effect of RA is, at least in part, mediated by induction of mitogen-activated protein kinase phosphatase 1

AB - Retinoic acid (RA) has been considered a proapoptotic agent, and little is known about its antiapoptotic potential. In this article, we describe that RA strongly inhibits hydrogen peroxide (H2O2)-induced apoptosis of mesangial cells by intervention in activator protein 1 (AP-1). Our data showed that: (i) H2O2 induces apoptosis of mesangial cells via the AP-1 pathway; (iii) activation of AP-1 by H2O2 is mediated by the c-Jun N-terminal kinase (JNK)-c-Jun/AP-1 pathway and the extracellular signal-regulated kinase-c-Fos/AP-1 pathway; (iii) RA inhibits H2O2-induced apoptosis via suppression of c-fos/c-jun expression and JNK activation; and (iv) the anti-apoptotic effect of RA is, at least in part, mediated by induction of mitogen-activated protein kinase phosphatase 1

U2 - 10.1093/ndt/17.suppl_9.84

DO - 10.1093/ndt/17.suppl_9.84

M3 - Article

SN - 1460-2385

VL - 17

SP - 84

EP - 87

JO - Nephrology, Dialysis, Transplantation

JF - Nephrology, Dialysis, Transplantation

IS - SUPPL. 9

ER -

Intervention by retinoic acid in oxidative stress-induced apoptosis

Abstract

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