Interventional multi-spectral photoacoustic imaging in laparoscopic surgery

TY - CHAP

T1 - Interventional multi-spectral photoacoustic imaging in laparoscopic surgery

AU - Hill, Emma R.

AU - Xia, Wenfeng

AU - Nikitichev, Daniil I.

AU - Gurusamy, Kurinchi

AU - Beard, Paul C.

AU - Hawkes, David J.

AU - Davidson, Brian R.

AU - Desjardins, Adrien E.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Laparoscopic procedures can be an attractive treatment option for liver resection, with a shortened hospital stay and reduced morbidity compared to open surgery. One of the central challenges of this technique is visualisation of concealed structures within the liver, particularly the vasculature and tumourous tissue. As photoacoustic (PA) imaging can provide contrast for haemoglobin in real time, it may be well suited to guiding laparoscopic procedures in order to avoid inadvertent trauma to vascular structures. In this study, a clinical laparoscopic ultrasound probe was used to receive ultrasound for PA imaging and to obtain co-registered B-mode ultrasound (US) images. Pulsed excitation light was delivered to the tissue via a fibre bundle in dark-field mode. Monte Carlo simulations were performed to optimise the light delivery geometry for imaging targets at depths of 1 cm, 2 cm and 3 cm, and 3D-printed mounts were used to position the fibre bundle relative to the transducer according to the simulation results. The performance of the photoacoustic laparoscope system was evaluated with phantoms and tissue models. The clinical potential of hybrid PA/US imaging to improve the guidance of laparoscopic surgery is discussed.

AB - Laparoscopic procedures can be an attractive treatment option for liver resection, with a shortened hospital stay and reduced morbidity compared to open surgery. One of the central challenges of this technique is visualisation of concealed structures within the liver, particularly the vasculature and tumourous tissue. As photoacoustic (PA) imaging can provide contrast for haemoglobin in real time, it may be well suited to guiding laparoscopic procedures in order to avoid inadvertent trauma to vascular structures. In this study, a clinical laparoscopic ultrasound probe was used to receive ultrasound for PA imaging and to obtain co-registered B-mode ultrasound (US) images. Pulsed excitation light was delivered to the tissue via a fibre bundle in dark-field mode. Monte Carlo simulations were performed to optimise the light delivery geometry for imaging targets at depths of 1 cm, 2 cm and 3 cm, and 3D-printed mounts were used to position the fibre bundle relative to the transducer according to the simulation results. The performance of the photoacoustic laparoscope system was evaluated with phantoms and tissue models. The clinical potential of hybrid PA/US imaging to improve the guidance of laparoscopic surgery is discussed.

KW - image guidance

KW - laparoscopy

KW - liver

KW - minimally invasive procedures

KW - Photoacoustic imaging

KW - ultrasound imaging

UR - http://www.scopus.com/inward/record.url?scp=84975038099&partnerID=8YFLogxK

U2 - 10.1117/12.2208428

DO - 10.1117/12.2208428

M3 - Conference paper

AN - SCOPUS:84975038099

VL - 9708

BT - Photons Plus Ultrasound

PB - SPIE

T2 - Photons Plus Ultrasound: Imaging and Sensing 2016

Y2 - 14 February 2016 through 17 February 2016

ER -