Intestinal iron absorption

TY - CHAP

T1 - Intestinal iron absorption

AU - McKie, Andrew

AU - Simpson, Robert

PY - 2011/11/24

Y1 - 2011/11/24

N2 - The last 15 years has seen tremendous advances made in our understanding, at the molecular level, of the proteins involved in iron transport and regulation of iron metabolism with the major players involved in intestinal non-heme iron transport now identified. This achievement comes after several decades had seen little progress in this area and it was the application of modern molecular biology techniques starting about 25 years ago that has revolutionized our understanding. Advances have also been made in understanding the regulation of iron absorption with the iron hormone hepcidin emerging as the key systemic regulator. Moreover, the regulation of hepcidin production by several well-known signal transduction pathways has been shown and the stage has now been reached where intervention treatments based on molecules which regulate hepcidin represent viable approaches to the treatment of iron disorders. The molecular regulation of the main intestinal proteins involved in iron absorption is well advanced. The present chapter will bring together recent findings on physiology, molecular biology, and biochemistry of iron absorption and attempt to provide an integrated view of the regulation of this process.

AB - The last 15 years has seen tremendous advances made in our understanding, at the molecular level, of the proteins involved in iron transport and regulation of iron metabolism with the major players involved in intestinal non-heme iron transport now identified. This achievement comes after several decades had seen little progress in this area and it was the application of modern molecular biology techniques starting about 25 years ago that has revolutionized our understanding. Advances have also been made in understanding the regulation of iron absorption with the iron hormone hepcidin emerging as the key systemic regulator. Moreover, the regulation of hepcidin production by several well-known signal transduction pathways has been shown and the stage has now been reached where intervention treatments based on molecules which regulate hepcidin represent viable approaches to the treatment of iron disorders. The molecular regulation of the main intestinal proteins involved in iron absorption is well advanced. The present chapter will bring together recent findings on physiology, molecular biology, and biochemistry of iron absorption and attempt to provide an integrated view of the regulation of this process.

U2 - 10.1007/978-1-60327-485-2

DO - 10.1007/978-1-60327-485-2

M3 - Chapter

SN - 978-1-60327-484-5

T3 - Nutrition and Health

SP - 101

EP - 116

BT - Iron Physiology and Pathophysiology in Humans

A2 - Anderson, Gregory

A2 - McLaren, GD

PB - Humana Press

ER -