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Intra- and inter-generic plasmid-mediated spread of cephalosporin and aminoglycoside resistance amongst Klebsiella aerogenes K41 and other enterobacteria

Research output: Contribution to journalArticle

A Verma, N Desai, K Shannon, J Philpott-Howard, R L R Hill

Original languageEnglish
Pages (from-to)123 - 129
Number of pages7
JournalINTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume17
Issue number2
DOIs
Published2001

King's Authors

Abstract

klebsiella aerogenes K41, resistant to third generation cephalosporins and aminoglycosides, was isolated From clinical samples of 153 in-patients. Blood cultures accounted for 24 (15.7%) of isolates. The MIG,,, of ceftazidime for thr isolates of 84 patients was >512 mg/l and was reduced to 2.0 by 4 mg/l of clavulanic acid, but only to 64 by 4 mg/l of sulbactam. Isolates of K. aerogenes K41 produced extended-spectrum beta -lactamase (ESBL) SHV-5 and TEM-1, identified by isoelectric focusing. Plasmid profiles showed that co-dissemination of cephalosporin and aminoglycoside resistance, plus ESBL production, coincided with the acquisition of a 116-kb plasmid. This plasmid was transferable in vitro from K. aerogenes K41 to other serotypes and genera of the Enterobacteriaceae. (C) 2001 Published by Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

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