Intracellular infections in Drosophila melanogaster: Host defense and mechanisms of pathogenesis

Claire B. Pean; Marc S. Dionne

doi:10.1016/j.dci.2013.04.013

Intracellular infections in Drosophila melanogaster: Host defense and mechanisms of pathogenesis

Claire B. Pean, Marc S. Dionne^*

^*Corresponding author for this work

Peter Gorer Department of Immunobiology

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The fruit-fly Drosophila melanogaster has emerged as a powerful model to study innate immunity against intracellular pathogens. To combat infection, the fly relies on multiple lines of defense, many of which are shared with mammals and arthropod vectors of human diseases. In addition to conserved immune pathways, the ease of performing sophisticated genetic screens has allowed the identification of novel host immune factors and novel pathogen virulence factors. Recently, some groups have exploited this to simultaneously analyze the host and pathogen genetics of intracellular infection. This review aims to unravel the Drosophila immune response against intracellular pathogens, highlighting recent discoveries.

Original language	English
Article number	N/A
Pages (from-to)	57-66
Number of pages	10
Journal	Developmental and Comparative Immunology
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/j.dci.2013.04.013
Publication status	Published - Jan 2014

Keywords

Drosophila
Intracellular infections
PEPTIDOGLYCAN RECOGNITION PROTEIN
LISTERIA-MONOCYTOGENES
INNATE IMMUNITY
RNAI SCREEN
FRANCISELLA-TULARENSIS
STAPHYLOCOCCUS-AUREUS
BACTERIAL-INFECTION
ANOPHELES-GAMBIAE
ESCHERICHIA-COLI
FRUIT-FLY

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dci.2013.04.013

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title = "Intracellular infections in Drosophila melanogaster: Host defense and mechanisms of pathogenesis",

abstract = "The fruit-fly Drosophila melanogaster has emerged as a powerful model to study innate immunity against intracellular pathogens. To combat infection, the fly relies on multiple lines of defense, many of which are shared with mammals and arthropod vectors of human diseases. In addition to conserved immune pathways, the ease of performing sophisticated genetic screens has allowed the identification of novel host immune factors and novel pathogen virulence factors. Recently, some groups have exploited this to simultaneously analyze the host and pathogen genetics of intracellular infection. This review aims to unravel the Drosophila immune response against intracellular pathogens, highlighting recent discoveries. ",

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author = "Pean, {Claire B.} and Dionne, {Marc S.}",

year = "2014",

month = jan,

doi = "10.1016/j.dci.2013.04.013",

language = "English",

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journal = "Developmental and Comparative Immunology",

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T1 - Intracellular infections in Drosophila melanogaster

T2 - Host defense and mechanisms of pathogenesis

AU - Pean, Claire B.

AU - Dionne, Marc S.

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N2 - The fruit-fly Drosophila melanogaster has emerged as a powerful model to study innate immunity against intracellular pathogens. To combat infection, the fly relies on multiple lines of defense, many of which are shared with mammals and arthropod vectors of human diseases. In addition to conserved immune pathways, the ease of performing sophisticated genetic screens has allowed the identification of novel host immune factors and novel pathogen virulence factors. Recently, some groups have exploited this to simultaneously analyze the host and pathogen genetics of intracellular infection. This review aims to unravel the Drosophila immune response against intracellular pathogens, highlighting recent discoveries.

AB - The fruit-fly Drosophila melanogaster has emerged as a powerful model to study innate immunity against intracellular pathogens. To combat infection, the fly relies on multiple lines of defense, many of which are shared with mammals and arthropod vectors of human diseases. In addition to conserved immune pathways, the ease of performing sophisticated genetic screens has allowed the identification of novel host immune factors and novel pathogen virulence factors. Recently, some groups have exploited this to simultaneously analyze the host and pathogen genetics of intracellular infection. This review aims to unravel the Drosophila immune response against intracellular pathogens, highlighting recent discoveries.

KW - Drosophila

KW - Intracellular infections

KW - PEPTIDOGLYCAN RECOGNITION PROTEIN

KW - LISTERIA-MONOCYTOGENES

KW - INNATE IMMUNITY

KW - RNAI SCREEN

KW - FRANCISELLA-TULARENSIS

KW - STAPHYLOCOCCUS-AUREUS

KW - BACTERIAL-INFECTION

KW - ANOPHELES-GAMBIAE

KW - ESCHERICHIA-COLI

KW - FRUIT-FLY

U2 - 10.1016/j.dci.2013.04.013

DO - 10.1016/j.dci.2013.04.013

M3 - Article

SN - 0145-305X

VL - 42

SP - 57

EP - 66

JO - Developmental and Comparative Immunology

JF - Developmental and Comparative Immunology

IS - 1

M1 - N/A

ER -

Intracellular infections in Drosophila melanogaster: Host defense and mechanisms of pathogenesis

Abstract

Keywords

UN SDGs

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