Intrahepatic Cholestasis of Pregnancy

Caroline Ovadia; Catherine Williamson

doi:10.1016/j.clindermatol.2016.02.004

Intrahepatic Cholestasis of Pregnancy

Caroline Ovadia, Catherine Williamson

Women & Children's Health

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Abstract

Abstract Intrahepatic cholestasis of pregnancy, also known as obstetric cholestasis, is a pruritic condition of pregnancy, characterized by an underlying elevation in circulating bile acids and liver derangement, and associated with adverse fetal outcomes, such as preterm labor and stillbirth. Limited understanding of the underlying pathophysiology and mechanisms involved in adverse outcomes has previously restricted treatment options and pregnancy management. Recent advances in these research fields provide tantalizing targets to improve the care of pregnant women affected by this condition.

Original language	English
Pages (from-to)	-
Journal	Clinics in Dermatology
DOIs	https://doi.org/10.1016/j.clindermatol.2016.02.004
Publication status	E-pub ahead of print - 10 Feb 2016

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1_s2.0_S0738081X16300190_mainAccepted author manuscript, 868 KB

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title = "Intrahepatic Cholestasis of Pregnancy",

abstract = "Abstract Intrahepatic cholestasis of pregnancy, also known as obstetric cholestasis, is a pruritic condition of pregnancy, characterized by an underlying elevation in circulating bile acids and liver derangement, and associated with adverse fetal outcomes, such as preterm labor and stillbirth. Limited understanding of the underlying pathophysiology and mechanisms involved in adverse outcomes has previously restricted treatment options and pregnancy management. Recent advances in these research fields provide tantalizing targets to improve the care of pregnant women affected by this condition.",

author = "Caroline Ovadia and Catherine Williamson",

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AU - Williamson, Catherine

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N2 - Abstract Intrahepatic cholestasis of pregnancy, also known as obstetric cholestasis, is a pruritic condition of pregnancy, characterized by an underlying elevation in circulating bile acids and liver derangement, and associated with adverse fetal outcomes, such as preterm labor and stillbirth. Limited understanding of the underlying pathophysiology and mechanisms involved in adverse outcomes has previously restricted treatment options and pregnancy management. Recent advances in these research fields provide tantalizing targets to improve the care of pregnant women affected by this condition.

AB - Abstract Intrahepatic cholestasis of pregnancy, also known as obstetric cholestasis, is a pruritic condition of pregnancy, characterized by an underlying elevation in circulating bile acids and liver derangement, and associated with adverse fetal outcomes, such as preterm labor and stillbirth. Limited understanding of the underlying pathophysiology and mechanisms involved in adverse outcomes has previously restricted treatment options and pregnancy management. Recent advances in these research fields provide tantalizing targets to improve the care of pregnant women affected by this condition.

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DO - 10.1016/j.clindermatol.2016.02.004

M3 - Article

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JO - Clinics in Dermatology

JF - Clinics in Dermatology

ER -

Intrahepatic Cholestasis of Pregnancy

Abstract

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