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Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila

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Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila. / Kottler, Benjamin; Faville, Richard; Bridi, Jessika Cristina; Hirth, Frank.

In: Current Biology, Vol. 29, No. 4, 18.02.2019, p. 567-577.e6.

Research output: Contribution to journalArticle

Harvard

Kottler, B, Faville, R, Bridi, JC & Hirth, F 2019, 'Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila', Current Biology, vol. 29, no. 4, pp. 567-577.e6. https://doi.org/10.1016/j.cub.2019.01.017

APA

Kottler, B., Faville, R., Bridi, J. C., & Hirth, F. (2019). Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila. Current Biology, 29(4), 567-577.e6. https://doi.org/10.1016/j.cub.2019.01.017

Vancouver

Kottler B, Faville R, Bridi JC, Hirth F. Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila. Current Biology. 2019 Feb 18;29(4):567-577.e6. https://doi.org/10.1016/j.cub.2019.01.017

Author

Kottler, Benjamin ; Faville, Richard ; Bridi, Jessika Cristina ; Hirth, Frank. / Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila. In: Current Biology. 2019 ; Vol. 29, No. 4. pp. 567-577.e6.

Bibtex Download

@article{a2c24f7a20e94351a32ea892b648ae01,
title = "Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila",
abstract = "{\textcopyright} 2019 The Authors Action selection is a prerequisite for decision-making and a fundamental aspect to any goal-directed locomotion; it requires integration of sensory signals and internal states to translate them into action sequences. Here, we introduce a novel behavioral analysis to study neural circuits and mechanisms underlying action selection and decision-making in freely moving Drosophila. We discovered preferred patterns of motor activity and turning behavior. These patterns are impaired in FoxP mutant flies, which present an altered temporal organization of motor actions and turning behavior, reminiscent of indecisiveness. Then, focusing on central complex (CX) circuits known to integrate different sensory modalities and controlling premotor regions, we show that action sequences and turning behavior are regulated by dopamine D1-like receptor (Dop1R1) signaling. Dop1R1 inputs onto CX columnar ellipsoid body-protocerebral bridge gall (E-PG) neuron and ellipsoid body (EB) R2/R4m ring neuron circuits both negatively gate motor activity but inversely control turning behavior. Although flies deficient of D1 receptor signaling present normal turning behavior despite decreased activity, restoring Dop1R1 level in R2/R4m-specific circuitry affects the temporal organization of motor actions and turning. We finally show EB R2/R4m neurons are in contact with E-PG neurons that are thought to encode body orientation and heading direction of the fly. These findings suggest that Dop1R1 signaling in E-PG and EB R2/4 m circuits are compared against each other, thereby modulating patterns of activity and turning behavior for goal-directed locomotion. Kottler et al. use a novel behavioral paradigm to show that dopamine D1-like receptor Dop1R1 signaling in columnar E-PG and ellipsoid body R2/R4m ring neurons mediate temporal patterns of activity and inversely control turning, suggesting that Dop1R1 levels between interconnected central complex circuitry modulate behavioral performance in flies.",
keywords = "action selection, brain, central complex, decision-making, dopamine, Drosophila, ellipsoid body, neural circuit, ring neuron, turning behavior",
author = "Benjamin Kottler and Richard Faville and Bridi, {Jessika Cristina} and Frank Hirth",
year = "2019",
month = feb,
day = "18",
doi = "10.1016/j.cub.2019.01.017",
language = "English",
volume = "29",
pages = "567--577.e6",
journal = "Current biology : CB",
issn = "0960-9822",
publisher = "Elsevier B.V.",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila

AU - Kottler, Benjamin

AU - Faville, Richard

AU - Bridi, Jessika Cristina

AU - Hirth, Frank

PY - 2019/2/18

Y1 - 2019/2/18

N2 - © 2019 The Authors Action selection is a prerequisite for decision-making and a fundamental aspect to any goal-directed locomotion; it requires integration of sensory signals and internal states to translate them into action sequences. Here, we introduce a novel behavioral analysis to study neural circuits and mechanisms underlying action selection and decision-making in freely moving Drosophila. We discovered preferred patterns of motor activity and turning behavior. These patterns are impaired in FoxP mutant flies, which present an altered temporal organization of motor actions and turning behavior, reminiscent of indecisiveness. Then, focusing on central complex (CX) circuits known to integrate different sensory modalities and controlling premotor regions, we show that action sequences and turning behavior are regulated by dopamine D1-like receptor (Dop1R1) signaling. Dop1R1 inputs onto CX columnar ellipsoid body-protocerebral bridge gall (E-PG) neuron and ellipsoid body (EB) R2/R4m ring neuron circuits both negatively gate motor activity but inversely control turning behavior. Although flies deficient of D1 receptor signaling present normal turning behavior despite decreased activity, restoring Dop1R1 level in R2/R4m-specific circuitry affects the temporal organization of motor actions and turning. We finally show EB R2/R4m neurons are in contact with E-PG neurons that are thought to encode body orientation and heading direction of the fly. These findings suggest that Dop1R1 signaling in E-PG and EB R2/4 m circuits are compared against each other, thereby modulating patterns of activity and turning behavior for goal-directed locomotion. Kottler et al. use a novel behavioral paradigm to show that dopamine D1-like receptor Dop1R1 signaling in columnar E-PG and ellipsoid body R2/R4m ring neurons mediate temporal patterns of activity and inversely control turning, suggesting that Dop1R1 levels between interconnected central complex circuitry modulate behavioral performance in flies.

AB - © 2019 The Authors Action selection is a prerequisite for decision-making and a fundamental aspect to any goal-directed locomotion; it requires integration of sensory signals and internal states to translate them into action sequences. Here, we introduce a novel behavioral analysis to study neural circuits and mechanisms underlying action selection and decision-making in freely moving Drosophila. We discovered preferred patterns of motor activity and turning behavior. These patterns are impaired in FoxP mutant flies, which present an altered temporal organization of motor actions and turning behavior, reminiscent of indecisiveness. Then, focusing on central complex (CX) circuits known to integrate different sensory modalities and controlling premotor regions, we show that action sequences and turning behavior are regulated by dopamine D1-like receptor (Dop1R1) signaling. Dop1R1 inputs onto CX columnar ellipsoid body-protocerebral bridge gall (E-PG) neuron and ellipsoid body (EB) R2/R4m ring neuron circuits both negatively gate motor activity but inversely control turning behavior. Although flies deficient of D1 receptor signaling present normal turning behavior despite decreased activity, restoring Dop1R1 level in R2/R4m-specific circuitry affects the temporal organization of motor actions and turning. We finally show EB R2/R4m neurons are in contact with E-PG neurons that are thought to encode body orientation and heading direction of the fly. These findings suggest that Dop1R1 signaling in E-PG and EB R2/4 m circuits are compared against each other, thereby modulating patterns of activity and turning behavior for goal-directed locomotion. Kottler et al. use a novel behavioral paradigm to show that dopamine D1-like receptor Dop1R1 signaling in columnar E-PG and ellipsoid body R2/R4m ring neurons mediate temporal patterns of activity and inversely control turning, suggesting that Dop1R1 levels between interconnected central complex circuitry modulate behavioral performance in flies.

KW - action selection

KW - brain

KW - central complex

KW - decision-making

KW - dopamine

KW - Drosophila

KW - ellipsoid body

KW - neural circuit

KW - ring neuron

KW - turning behavior

UR - http://www.scopus.com/inward/record.url?scp=85061399800&partnerID=8YFLogxK

U2 - 10.1016/j.cub.2019.01.017

DO - 10.1016/j.cub.2019.01.017

M3 - Article

C2 - 30713106

AN - SCOPUS:85061399800

VL - 29

SP - 567-577.e6

JO - Current biology : CB

JF - Current biology : CB

SN - 0960-9822

IS - 4

ER -

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