Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry

Isabel Ng; Alexandra Bonthrone; Christopher Kelly; Lucilio Cordero-Grande; Emer Hughes; Anthony Price; Jana Hutter; Suresh Victor; Andreas Schuh; Daniel Rueckert; Jo Hajnal; John Simpson; David Edwards; Mary Rutherford; Dafnis Batalle; Serena Counsell

doi:10.1038/s41598-020-72009-3

Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry

Isabel Ng, Alexandra Bonthrone, Christopher Kelly, Lucilio Cordero-Grande, Emer Hughes, Anthony Price, Jana Hutter, Suresh Victor, Andreas Schuh, Daniel Rueckert, Jo Hajnal, John Simpson, David Edwards, Mary Rutherford, Dafnis Batalle, Serena Counsell

Centre for the Developing Brain and Department of Biomedical Engineering, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners; St Thomas' Hospital; London UK
Centre for the Developing Brain

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Abstract

Magnetic resonance (MR) imaging studies have demonstrated reduced global and regional brain volumes in infants with congenital heart disease (CHD). This study aimed to provide a more detailed evaluation of altered structural brain development in newborn infants with CHD compared to healthy controls using tensor-based morphometry (TBM). We compared brain development in 64 infants with CHD to 192 age- and sex-matched healthy controls. T2-weighted MR images obtained prior to surgery were analysed to compare voxel-wise differences in structure across the whole brain between groups. Cerebral oxygen delivery (CDO ₂) was measured in infants with CHD (n = 49) using phase contrast MR imaging and the relationship between CDO ₂ and voxel-wise brain structure was assessed using TBM. After correcting for global scaling differences, clusters of significant volume reduction in infants with CHD were demonstrated bilaterally within the basal ganglia, thalami, corpus callosum, occipital, temporal, parietal and frontal lobes, and right hippocampus (p < 0.025 after family-wise error correction). Clusters of significant volume expansion in infants with CHD were identified in cerebrospinal fluid spaces (p < 0.025). After correcting for global brain size, there was no significant association between voxel-wise brain structure and CDO ₂. This study localizes abnormal brain development in infants with CHD, identifying areas of particular vulnerability.

Original language	English
Article number	14909
Journal	Nature Scientific Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-72009-3
Publication status	Published - 1 Dec 2020

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2020_8_Ng_ScientificReportsFinal published version, 1.26 MBLicence: CC BY

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Ng, I., Bonthrone, A., Kelly, C., Cordero-Grande, L., Hughes, E., Price, A., Hutter, J., Victor, S., Schuh, A., Rueckert, D., Hajnal, J., Simpson, J., Edwards, D., Rutherford, M., Batalle, D., & Counsell, S. (2020). Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry. Nature Scientific Reports, 10(1), Article 14909. https://doi.org/10.1038/s41598-020-72009-3

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title = "Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry",

abstract = "Magnetic resonance (MR) imaging studies have demonstrated reduced global and regional brain volumes in infants with congenital heart disease (CHD). This study aimed to provide a more detailed evaluation of altered structural brain development in newborn infants with CHD compared to healthy controls using tensor-based morphometry (TBM). We compared brain development in 64 infants with CHD to 192 age- and sex-matched healthy controls. T2-weighted MR images obtained prior to surgery were analysed to compare voxel-wise differences in structure across the whole brain between groups. Cerebral oxygen delivery (CDO 2) was measured in infants with CHD (n = 49) using phase contrast MR imaging and the relationship between CDO 2 and voxel-wise brain structure was assessed using TBM. After correcting for global scaling differences, clusters of significant volume reduction in infants with CHD were demonstrated bilaterally within the basal ganglia, thalami, corpus callosum, occipital, temporal, parietal and frontal lobes, and right hippocampus (p < 0.025 after family-wise error correction). Clusters of significant volume expansion in infants with CHD were identified in cerebrospinal fluid spaces (p < 0.025). After correcting for global brain size, there was no significant association between voxel-wise brain structure and CDO 2. This study localizes abnormal brain development in infants with CHD, identifying areas of particular vulnerability. ",

author = "Isabel Ng and Alexandra Bonthrone and Christopher Kelly and Lucilio Cordero-Grande and Emer Hughes and Anthony Price and Jana Hutter and Suresh Victor and Andreas Schuh and Daniel Rueckert and Jo Hajnal and John Simpson and David Edwards and Mary Rutherford and Dafnis Batalle and Serena Counsell",

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Ng, I, Bonthrone, A, Kelly, C, Cordero-Grande, L, Hughes, E, Price, A , Hutter, J , Victor, S, Schuh, A, Rueckert, D, Hajnal, J , Simpson, J , Edwards, D , Rutherford, M , Batalle, D & Counsell, S 2020, 'Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry', Nature Scientific Reports, vol. 10, no. 1, 14909. https://doi.org/10.1038/s41598-020-72009-3

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T1 - Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry

AU - Ng, Isabel

AU - Bonthrone, Alexandra

AU - Kelly, Christopher

AU - Cordero-Grande, Lucilio

AU - Hughes, Emer

AU - Price, Anthony

AU - Hutter, Jana

AU - Victor, Suresh

AU - Schuh, Andreas

AU - Rueckert, Daniel

AU - Hajnal, Jo

AU - Simpson, John

AU - Edwards, David

AU - Rutherford, Mary

AU - Batalle, Dafnis

AU - Counsell, Serena

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Magnetic resonance (MR) imaging studies have demonstrated reduced global and regional brain volumes in infants with congenital heart disease (CHD). This study aimed to provide a more detailed evaluation of altered structural brain development in newborn infants with CHD compared to healthy controls using tensor-based morphometry (TBM). We compared brain development in 64 infants with CHD to 192 age- and sex-matched healthy controls. T2-weighted MR images obtained prior to surgery were analysed to compare voxel-wise differences in structure across the whole brain between groups. Cerebral oxygen delivery (CDO 2) was measured in infants with CHD (n = 49) using phase contrast MR imaging and the relationship between CDO 2 and voxel-wise brain structure was assessed using TBM. After correcting for global scaling differences, clusters of significant volume reduction in infants with CHD were demonstrated bilaterally within the basal ganglia, thalami, corpus callosum, occipital, temporal, parietal and frontal lobes, and right hippocampus (p < 0.025 after family-wise error correction). Clusters of significant volume expansion in infants with CHD were identified in cerebrospinal fluid spaces (p < 0.025). After correcting for global brain size, there was no significant association between voxel-wise brain structure and CDO 2. This study localizes abnormal brain development in infants with CHD, identifying areas of particular vulnerability.

AB - Magnetic resonance (MR) imaging studies have demonstrated reduced global and regional brain volumes in infants with congenital heart disease (CHD). This study aimed to provide a more detailed evaluation of altered structural brain development in newborn infants with CHD compared to healthy controls using tensor-based morphometry (TBM). We compared brain development in 64 infants with CHD to 192 age- and sex-matched healthy controls. T2-weighted MR images obtained prior to surgery were analysed to compare voxel-wise differences in structure across the whole brain between groups. Cerebral oxygen delivery (CDO 2) was measured in infants with CHD (n = 49) using phase contrast MR imaging and the relationship between CDO 2 and voxel-wise brain structure was assessed using TBM. After correcting for global scaling differences, clusters of significant volume reduction in infants with CHD were demonstrated bilaterally within the basal ganglia, thalami, corpus callosum, occipital, temporal, parietal and frontal lobes, and right hippocampus (p < 0.025 after family-wise error correction). Clusters of significant volume expansion in infants with CHD were identified in cerebrospinal fluid spaces (p < 0.025). After correcting for global brain size, there was no significant association between voxel-wise brain structure and CDO 2. This study localizes abnormal brain development in infants with CHD, identifying areas of particular vulnerability.

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Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry

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