Investigating incretin-based therapies as a novel treatment for depression in type 2 diabetes: Findings from the South London Diabetes (SOUL-D) Study

TY - JOUR

T1 - Investigating incretin-based therapies as a novel treatment for depression in type 2 diabetes

T2 - Findings from the South London Diabetes (SOUL-D) Study

AU - Moulton, C. D.

AU - Pickup, J. C.

AU - Amiel, S. A.

AU - Winkley, K.

AU - Ismail, K.

PY - 2016/4

Y1 - 2016/4

N2 - We aimed to investigate the association between incretin-based therapies and 1-year change in depressive symptoms in a cohort of 1735 patients with newly diagnosed type 2 diabetes. The incretin group experienced significant reduction in depressive symptoms compared to controls. This was independent of HbA1c and may be mediated by an anti-inflammatory mechanism.

AB - We aimed to investigate the association between incretin-based therapies and 1-year change in depressive symptoms in a cohort of 1735 patients with newly diagnosed type 2 diabetes. The incretin group experienced significant reduction in depressive symptoms compared to controls. This was independent of HbA1c and may be mediated by an anti-inflammatory mechanism.

KW - Depressive symptoms

KW - Incretin-based therapies

KW - Inflammation

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=84959195239&partnerID=8YFLogxK

U2 - 10.1016/j.pcd.2015.06.003

DO - 10.1016/j.pcd.2015.06.003

M3 - Article

AN - SCOPUS:84959195239

SN - 1751-9918

VL - 10

SP - 156

EP - 159

JO - Primary Care Diabetes

JF - Primary Care Diabetes

IS - 2

ER -