Investigating low-velocity fluid flow in tumors with convection-MRI

TY - JOUR

T1 - Investigating low-velocity fluid flow in tumors with convection-MRI

AU - Walker-Samuel, Simon

AU - Roberts, Thomas A.

AU - Ramasawmy, Rajiv

AU - Burrell, Jake S.

AU - Johnson, Sean Peter

AU - Siow, Bernard M.

AU - Richardson, Simon

AU - Gonçalves, Miguel R.

AU - Pendse, Douglas

AU - Robinson, Simon P.

AU - Barbara Pedley, R.

AU - Lythgoe, Mark F.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Several distinct fluid flow phenomena occur in solid tumors, including intravascular blood flow and interstitial convection. Interstitial fluid pressure is often raised in solid tumors, which can limit drug delivery. To probe low-velocity flow in tumors resulting from raised interstitial fluid pressure, we developed a novel MRI technique named convection-MRI, which uses a phase-contrast acquisition with a dual-inversion vascular nulling preparation to separate intra- and extravascular flow. Here, we report the results of experiments in flow phantoms, numerical simulations, and tumor xenograft models to investigate the technical feasibility of convection-MRI. We observed a significant correlation between estimates of effective fluid pressure from convection-MRI with gold-standard, invasive measurements of interstitial fluid pressure in mouse models of human colorectal carcinoma. Our results show how convection-MRI can provide insights into the growth and responsiveness to vascular-targeting therapy in colorectal cancers. Significance: A noninvasive method for measuring low-velocity fluid flow caused by raised fluid pressure can be used to assess changes caused by therapy.

AB - Several distinct fluid flow phenomena occur in solid tumors, including intravascular blood flow and interstitial convection. Interstitial fluid pressure is often raised in solid tumors, which can limit drug delivery. To probe low-velocity flow in tumors resulting from raised interstitial fluid pressure, we developed a novel MRI technique named convection-MRI, which uses a phase-contrast acquisition with a dual-inversion vascular nulling preparation to separate intra- and extravascular flow. Here, we report the results of experiments in flow phantoms, numerical simulations, and tumor xenograft models to investigate the technical feasibility of convection-MRI. We observed a significant correlation between estimates of effective fluid pressure from convection-MRI with gold-standard, invasive measurements of interstitial fluid pressure in mouse models of human colorectal carcinoma. Our results show how convection-MRI can provide insights into the growth and responsiveness to vascular-targeting therapy in colorectal cancers. Significance: A noninvasive method for measuring low-velocity fluid flow caused by raised fluid pressure can be used to assess changes caused by therapy.

UR - http://www.scopus.com/inward/record.url?scp=85047870125&partnerID=8YFLogxK

U2 - 10.1158/0008-5472.CAN-17-1546

DO - 10.1158/0008-5472.CAN-17-1546

M3 - Article

C2 - 29317434

AN - SCOPUS:85047870125

SN - 0008-5472

VL - 78

SP - 1859

EP - 1872

JO - Cancer Research

JF - Cancer Research

IS - 7

ER -