TY - CHAP
T1 - Investigation of Low-Voltage Defibrillation by Standing Waves in Human Ventricular Tissue Models
AU - Georgiev, Nikolay
AU - Connolly, Adam
AU - Bishop, Martin
AU - Aslanidi, Oleg
N1 - Funding Information:
This work was supported by the Wellcome/EPSRC Centre for Medical Engineering [WT 203148/Z/16/Z].
Publisher Copyright:
© 2021 Creative Commons.
PY - 2021
Y1 - 2021
N2 - Ventricular fibrillation (VF) is one of the main causes of sudden cardiac death. Strong electric shocks remain the only reliable mechanism for successful termination of VF, but often lead to post-injuries. This study aims to explore whether low-voltage shocks at certain frequencies could result in successful defibrillation of human ventricular tissue. 1 D and 2D ventricular tissue models were based on the Ten Tusscher et al. myocyte model combined with an extended version of the bidomain model with an external bath, to which the electric shocks were delivered. Sinusoidal low-voltage (10-50 Hz, 20-40 V) shocks were applied at opposite sides of 1D tissue strands and 2D square tissues of variable sizes; in 2D models, VF was induced in form of a single re-entrant wave. In 1 D models, standing waves were observed at all frequencies in short ventricular strands (1-2 cm, comparable to the transmural distance in the human ventricles), but not in long strands (5-10 cm). Accordingly, in 2D tissue models of 5-10 cm2, standing waves failed to form and terminate re-entry; otherwise, electrical waves originating from the shock application sites led to the generation of additional reentries. In summary, the formation of standing waves due to periodic low-voltage stimulation of human ventricular tissue can lead to defibrillation of transmural re-entrant waves, but not of rotors on the ventricular surface.
AB - Ventricular fibrillation (VF) is one of the main causes of sudden cardiac death. Strong electric shocks remain the only reliable mechanism for successful termination of VF, but often lead to post-injuries. This study aims to explore whether low-voltage shocks at certain frequencies could result in successful defibrillation of human ventricular tissue. 1 D and 2D ventricular tissue models were based on the Ten Tusscher et al. myocyte model combined with an extended version of the bidomain model with an external bath, to which the electric shocks were delivered. Sinusoidal low-voltage (10-50 Hz, 20-40 V) shocks were applied at opposite sides of 1D tissue strands and 2D square tissues of variable sizes; in 2D models, VF was induced in form of a single re-entrant wave. In 1 D models, standing waves were observed at all frequencies in short ventricular strands (1-2 cm, comparable to the transmural distance in the human ventricles), but not in long strands (5-10 cm). Accordingly, in 2D tissue models of 5-10 cm2, standing waves failed to form and terminate re-entry; otherwise, electrical waves originating from the shock application sites led to the generation of additional reentries. In summary, the formation of standing waves due to periodic low-voltage stimulation of human ventricular tissue can lead to defibrillation of transmural re-entrant waves, but not of rotors on the ventricular surface.
UR - http://www.scopus.com/inward/record.url?scp=85124715088&partnerID=8YFLogxK
U2 - 10.23919/CinC53138.2021.9662774
DO - 10.23919/CinC53138.2021.9662774
M3 - Conference paper
AN - SCOPUS:85124715088
T3 - Computing in Cardiology
BT - 2021 Computing in Cardiology, CinC 2021
PB - IEEE Computer Society
T2 - 2021 Computing in Cardiology, CinC 2021
Y2 - 13 September 2021 through 15 September 2021
ER -