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Investigation of phase-contrast magnetic resonance imaging underestimation of turbulent flow through the aortic valve phantom: Experimental and computational study using lattice Boltzmann method

Research output: Contribution to journalArticle

Radek Fucik, Radek Galabov, Petr Paus, Pavel Eichler, Jakub Klinkovsky, Robert Straka, Jaroslav Tintera, Radomir Chabiniok

Original languageEnglish
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Early online date27 Feb 2020
Publication statusE-pub ahead of print - 27 Feb 2020

King's Authors

Abstract

Objective: The accuracy of phase-contrast magnetic resonance imaging (PC-MRI) measurement is investigated using a computational fluid dynamics (CFD) model with the objective to determine the magnitude of the flow underestimation due to turbulence behind a narrowed valve in a phantom experiment. Materials and Methods: An acrylic stationary flow phantom is used with three insertable plates mimicking aortic valvular stenoses of varying degrees. Positive and negative horizontal fluxes are measured at equidistant slices using standard PC-MRI sequences by 1.5T and 3T systems. The CFD model is based on the 3D lattice Boltzmann method (LBM). The experimental and simulated data are compared using the Bland-Altman-derived limits of agreement. Based on the LBM results, the turbulence is quantified and confronted with the level of flow underestimation. Results: LBM gives comparable results to PC-MRI for valves up to moderate stenosis on both field strengths. The flow magnitude through a severely stenotic valve was underestimated due to signal void in the regions of turbulent flow behind the valve, consistently with the level of quantified turbulence intensity. Discussion: Flow measured by PC-MRI is affected by noise and turbulence. LBM can simulate turbulent flow efficiently and accurately, it has therefore the potential to improve clinical interpretation of PC-MRI.

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